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Mech Dev：研究揭示Tricin促进成骨细胞生成的机制

2018-09-04 MedSci MedSci原创

关注

间充质干细胞（MSCs）是多能基质细胞，其能够在体外和体内分化成多系细胞类型，包括骨。MSCs已被广泛开发为骨组织修复和再生的治疗方法。然而，谱系特异性分化的效率仍然需要改进。我们通过阿拉玛蓝试验研究了Tricin对人成体MSCs增殖的影响，通过钙沉积染色对MSCs的矿化作用以及MSCs成骨分化过程中成骨细胞标记基因的表达水平进行了研究。此外，我们还检查了Tricin对Wnt/β-catenin信

间充质干细胞（MSCs）是多能基质细胞，其能够在体外和体内分化成多系细胞类型，包括骨。MSCs已被广泛开发为骨组织修复和再生的治疗方法。然而，谱系特异性分化的效率仍然需要改进。

我们通过阿拉玛蓝试验研究了Tricin对人成体MSCs增殖的影响，通过钙沉积染色对MSCs的矿化作用以及MSCs成骨分化过程中成骨细胞标记基因的表达水平进行了研究。此外，我们还检查了Tricin对Wnt/β-catenin信号通路中关键基因表达的影响。

结果显示，Tricin可以促进MSCs的增殖及矿化。Tricin还可以增强骨形成标记基因的表达，包括骨涎蛋白、骨钙蛋白、碱性磷酸酶和RUNX2。此外，我们发现siβ-连环蛋白和GSK-3β都不会对Tricin处理产生影响，但是siWnt3α可以中和Tricin的作用。

综上所述，该研究结果表明，Tricin可通过体外调节人成体MSCs中的Wnt/β-catenin信号通路来增强成骨细胞生成。

原始出处：

Zhang H, Li H. Tricin enhances osteoblastogenesis through the regulation of Wnt/β-catenin signaling in human mesenchymal stem cells. Mech Dev. 2018 Aug;152:38-43. doi: 10.1016/j.mod.2018.07.001. Epub 2018 Jul 2.

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    2019-04-14 fzwish20000

    #Dev#

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    2019-02-16 kalseyzl

    #CIN#

    0

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    2018-09-10 深海的鱼

    学习学习学习

    0

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    2018-09-06 zhaojie88

    #成骨#

    0

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    2018-09-06 jj000004

    #骨细胞#

    0

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    2018-09-05 ylzr123

    感谢小编为我们准备了如此丰盛的精神大餐，同时也向作者致谢！认真学习了，点赞！

    0

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    2018-09-05 明月清辉

    谢谢分享，学习了

    0

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    2018-09-05 1209e435m98(暂无昵称)

    学习了，谢谢分享

    0

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    2018-09-05 liumin1987

    嗯嗯，学习了。

    0