Diabetes Care:糖尿病嗅探犬可闻出糖尿病气味

2016-06-29 佚名 生物谷

剑桥大学的新研究显示,我们的呼吸气体中存在一种化学成分,这种成分可以对I型糖尿病患者低血糖水平发出警告。该研究今天发表在《Diabetes Care》杂志上,这样就可以解释为什么有些狗可以被训练到能够闻出病人的警告信号。Claire Pesterfield患有I型糖尿病,她需要注射胰岛素来控制血糖水平。她有一个金色的拉布拉多犬被慈善医疗检测犬机构训练,当她的血糖水平下降到危险值时训练犬可以发出警告

剑桥大学的新研究显示,我们的呼吸气体中存在一种化学成分,这种成分可以对I型糖尿病患者低血糖水平发出警告。该研究今天发表在《Diabetes Care》杂志上,这样就可以解释为什么有些狗可以被训练到能够闻出病人的警告信号。

Claire Pesterfield患有I型糖尿病,她需要注射胰岛素来控制血糖水平。她有一个金色的拉布拉多犬被慈善医疗检测犬机构训练,当她的血糖水平下降到危险值时训练犬可以发出警告。

“低血糖会威胁我的日常生活,如果血糖降得太低的话是非常危险的。”Claire 说。“Magic不仅仅是一个好的伴侣,而且它是我的“鼻子”,如果我处于危险之中的话它会及时警告我。如果它闻到了气味就会跳起来把它的爪子放在我肩膀让我知道。”

低血糖会导致颤抖,定向障碍和疲劳等问题,如果病人血糖没有及时得到补充就可能导致癫痫发作,并导致意识不清。在某些糖尿病患者中,这种事情可能会毫无预兆的突然发生。

犬类发出的警告提醒主人血糖变化,研究人员相信某些呼出的气息中自然产生的化学物质在血糖水平较低时可能会发生改变。在初步研究中研究人员测试了这一假说,科学家们对8名女性进行了测试,他们逐渐降低了研究对象的血糖水平一直达到血糖危险水平,所有的研究对象均在40岁左右,都患有I型糖尿病。然后使用质谱分析法检测这些化学物质。

研究人员发现,在低血糖时,呼吸中异戊二烯的化学物质含量显著上升——在某些情况下几乎会翻倍。研究人员认为犬类可能对异戊二烯的存在比较敏感。这表明人们有可能开发出新的探测器,该仪器可以识别呼吸中有高浓度异戊二烯的处于危险中的病人。

“异戊二烯是一种最常见的天然化学物质,我们发现在人类的呼吸中存在这种物质,但我们却极少了解它从哪里来。”Mark Evans博士说。“我们怀疑这是胆固醇产物的一个副产物,但目前还不清楚为什么当病人血糖很低时这种化学物质含量会上升。”

“人类对异戊二烯的存在并不敏感,但是犬类难以置信的嗅觉可以训练得很容易识别并提醒处于低血糖危险状况时的主人。异戊二烯提供了一种“气味”,可以帮助我们开发一种新的测试方法,用来检测糖尿病患者低血糖并减少潜在的威胁生命的并发症发生。”

原始出处

Sankalpa Neupane1, Robert Peverall2,3, Graham Richmond2, Tom P.J. Blaikie2, David Taylor2, Gus Hancock2,3 and Mark L. Evans1⇑.Exhaled Breath Isoprene Rises During Hypoglycemia in Type 1 Diabetes.Diabetes Care.2016

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    2018-01-03 1e145228m78(暂无匿称)

    学习了谢谢作者分享!

    0

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  3. [GetPortalCommentsPageByObjectIdResponse(id=274882, encodeId=cac02e48823c, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Wed Jan 03 00:40:47 CST 2018, time=2018-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901402, encodeId=fd381901402b4, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Fri Jul 29 18:28:00 CST 2016, time=2016-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=132077, encodeId=916e1320e778, content=文章很好,非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Sep 21 08:22:00 CST 2016, time=2016-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125752, encodeId=40a3125e529c, content=开发新型的简单的监测方式确实是一个很好的思路,感谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Tue Sep 13 21:40:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759699, encodeId=60401e59699a6, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Wed Aug 03 20:28:00 CST 2016, time=2016-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637378, encodeId=936c163e37862, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun Nov 20 16:28:00 CST 2016, time=2016-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91593, encodeId=5ecf91593dc, content=其实糖尿病患者的同振,以及散发出一些代谢组学的这些气味确实可以被识别,也许将来不是动物识别,而是一些,敏锐的传感器。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Wed Jun 29 23:55:00 CST 2016, time=2016-06-29, status=1, ipAttribution=)]
    2016-09-21 1e10c84am36(暂无匿称)

    文章很好,非常有益

    0

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    2016-09-13 舒心和人

    开发新型的简单的监测方式确实是一个很好的思路,感谢分享,学习了

    0

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    2016-06-29 lovetcm

    其实糖尿病患者的同振,以及散发出一些代谢组学的这些气味确实可以被识别,也许将来不是动物识别,而是一些,敏锐的传感器。

    0

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