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Clinica Chimica Acta：妊娠期糖尿病尿小分子肽的筛选与分析

2020-04-12 MedSci原创 MedSci原创

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妊娠期糖尿病(GDM)是一种临床常见病，临床过程复杂，对孕妇和胎儿有不良影响。本研究的目的是利用方便的尿液样本结合血糖水平来检测或预测GDM。本研究收集了非孕妇、正常孕妇和GDM患者的尿液样本。

妊娠期糖尿病(GDM)是一种临床常见病，临床过程复杂，对孕妇和胎儿有不良影响。本研究的目的是利用方便的尿液样本结合血糖水平来检测或预测GDM。本研究收集了非孕妇、正常孕妇和GDM患者的尿液样本。利用弱阳离子交换磁珠(MB-WCX)富集尿液中的多肽，并采用基质辅助激光解吸电离飞行时间质谱法(MALDI-TOF MS)进行分析。利用Bioexplorer分析软件筛选出46个具有统计学差异(P < 0.01)的多肽峰。GDM组的分子质量荷电比分别为1079.2、1290.6、1500.7。通过液相色谱串联质谱法（LC-MS）分析差异分子，上述分子被鉴定为凝血因子IX，TBC1家族成员5同工型[智人]（TBC1D5a）和免疫球蛋白κ常数。。

多肽的发现为进一步通过尿液标本进行GDM的初筛和辅助诊断提供了研究基础。

原始出处：

Zhiying Hu，Man Zhang，Screening and analysis of small molecular peptides in urine of gestational diabetes mellitus

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    2020-07-08 宋威

    #小分子#

    0

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    2021-02-06 windight

    #CTA#

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    2020-04-14 wjcjjian

    #妊娠期#

    0

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    2020-04-14 shenxlcyp

    #妊娠期糖尿病#

    0

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    2020-04-14 ms6747015003810650

    #筛选#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1914701, encodeId=c1e31914e0120, content=<a href='/topic/show?id=84d7469559b' target=_blank style='color:#2F92EE;'>#小分子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46955, encryptionId=84d7469559b, topicName=小分子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Wed Jul 08 23:39:21 CST 2020, time=2020-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849903, encodeId=857c1849903db, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sat Feb 06 23:39:21 CST 2021, time=2021-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251248, encodeId=c6d11251248c2, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Tue Apr 14 12:39:21 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253661, encodeId=eb1e125366120, content=<a href='/topic/show?id=9d5d44888a9' target=_blank style='color:#2F92EE;'>#妊娠期糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44888, encryptionId=9d5d44888a9, topicName=妊娠期糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Tue Apr 14 12:39:21 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584439, encodeId=29631584439f8, content=<a href='/topic/show?id=9bbee5948f0' target=_blank style='color:#2F92EE;'>#筛选#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75948, encryptionId=9bbee5948f0, topicName=筛选)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=39da17047364, createdName=ms6747015003810650, createdTime=Tue Apr 14 12:39:21 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043067, encodeId=644e104306e28, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Apr 13 00:39:21 CST 2020, time=2020-04-13, status=1, ipAttribution=)]
    2020-04-13 misszhang

    谢谢MedSci提供最新的资讯

    0