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Acta Biomater：介孔聚合物来源的Ca-Mg硅酸盐陶瓷具有良好的骨再生性能

2018-01-23 MedSci MedSci原创

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镁是人体内的微量元素，已知对钙化组织的细胞分化和矿化有重要作用。这项研究旨在从陶瓷聚合物合成高孔隙率的Ca-Mg硅酸盐发泡支架，并分析其生物学反应。通过与反应性填料混合的液体硅氧烷的热解而获得Akermanite（Ak）和硅灰石-透辉石（WD）陶瓷泡沫体。多孔结构是通过在350℃下从选定的填料（氢氧化镁和硼砂）控制释放水而获得的。在1100℃烧结后，得到160-180μm模态直径相互连接的孔，且均

镁是人体内的微量元素，已知对钙化组织的细胞分化和矿化有重要作用。这项研究旨在从陶瓷聚合物合成高孔隙率的Ca-Mg硅酸盐发泡支架，并分析其生物学反应。

通过与反应性填料混合的液体硅氧烷的热解而获得Akermanite（Ak）和硅灰石-透辉石（WD）陶瓷泡沫体。多孔结构是通过在350℃下从选定的填料（氢氧化镁和硼砂）控制释放水而获得的。在1100℃烧结后，得到160-180μm模态直径相互连接的孔，且均匀分布。泡沫材料的孔隙率超过80％，抗压强度值为1-2MPa。通过在SBF中浸泡21天进行体外研究，显示材料具有合适的溶解速率、pH和离子浓度。根据ISO10993-5和ISO10993-12标准进行的细胞毒性分析证实Ak和WD泡沫都具有优异的生物相容性。此外，与无镁支架相比，在含镁支架上培养的MC3T3-E1细胞，表现出增强的成骨分化和成骨标志物（包括I型胶原蛋白，骨桥蛋白和骨钙蛋白）的表达。

综上所述，该结果表明，镁的添加可进一步增强生物活性和硅酸钙材料的骨再生应用的可能性。

原始出处：

Fiocco L, Li S, et al., Biocompatibility and bioactivity of porous polymer-derived Ca-Mg silicate ceramics. Acta Biomater. 2017 Mar 1;50:56-67. doi: 10.1016/j.actbio.2016.12.043. Epub 2016 Dec 23.

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    2018-09-15 windight

    #CTA#

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    2018-10-27 redcrab

    #陶瓷#

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    2018-04-21 luckyshitiancai_42705692

    #介孔#

    0

  4. 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style='color:#2F92EE;'>#聚合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80794, encryptionId=98bc80e9418, topicName=聚合物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bf611326764, createdName=yese, createdTime=Thu Jan 25 13:32:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281410, encodeId=c74b28141005, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Jan 24 00:05:56 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281392, encodeId=98bc281392e0, content=很好的文章.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Jan 23 23:24:45 CST 2018, time=2018-01-23, status=1, ipAttribution=)]
    2018-11-01 sunylz

    #Bio#

    0

  5. 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    2018-01-31 周周人

    学习.

    0

  6. 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    2018-01-30 1e16d8a5m40(暂无匿称)

    学习啦

    0

  7. 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style='color:#2F92EE;'>#聚合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80794, encryptionId=98bc80e9418, topicName=聚合物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bf611326764, createdName=yese, createdTime=Thu Jan 25 13:32:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281410, encodeId=c74b28141005, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Jan 24 00:05:56 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281392, encodeId=98bc281392e0, content=很好的文章.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Jan 23 23:24:45 CST 2018, time=2018-01-23, status=1, ipAttribution=)]
    2018-01-25 lsj630

    #骨再生#

    0

  8. 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encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Nov 01 18:32:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283905, encodeId=eada2839056a, content=学习., beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcVAydhtcpjiaxLrZD7Eb5YnKPgf7ypGpfyl7FflFyAenvQLbib6T0LPXIhXo9SPNPXYYFFJbEgykztwJ0HQ61I3F9GxIVKWsgQ/0, createdBy=f38d2052407, createdName=周周人, createdTime=Wed Jan 31 19:42:34 CST 2018, time=2018-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283551, encodeId=110d2835513f, content=学习啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211120/0a343dd652314c849f92187e706a0203/030af22773fe40d69835eedc02230010.jpg, createdBy=0a471975170, createdName=1e16d8a5m40(暂无匿称), createdTime=Tue Jan 30 17:16:10 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472107, encodeId=297114e210718, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Thu Jan 25 13:32:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521283, encodeId=1a67152128322, content=<a href='/topic/show?id=98bc80e9418' target=_blank style='color:#2F92EE;'>#聚合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80794, encryptionId=98bc80e9418, topicName=聚合物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bf611326764, createdName=yese, createdTime=Thu Jan 25 13:32:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281410, encodeId=c74b28141005, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Jan 24 00:05:56 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281392, encodeId=98bc281392e0, content=很好的文章.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Jan 23 23:24:45 CST 2018, time=2018-01-23, status=1, ipAttribution=)]
    2018-01-25 yese

    #聚合物#

    0

  9. 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encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Nov 01 18:32:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283905, encodeId=eada2839056a, content=学习., beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcVAydhtcpjiaxLrZD7Eb5YnKPgf7ypGpfyl7FflFyAenvQLbib6T0LPXIhXo9SPNPXYYFFJbEgykztwJ0HQ61I3F9GxIVKWsgQ/0, createdBy=f38d2052407, createdName=周周人, createdTime=Wed Jan 31 19:42:34 CST 2018, time=2018-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283551, encodeId=110d2835513f, content=学习啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211120/0a343dd652314c849f92187e706a0203/030af22773fe40d69835eedc02230010.jpg, createdBy=0a471975170, createdName=1e16d8a5m40(暂无匿称), createdTime=Tue Jan 30 17:16:10 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472107, encodeId=297114e210718, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Thu Jan 25 13:32:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521283, encodeId=1a67152128322, content=<a href='/topic/show?id=98bc80e9418' target=_blank style='color:#2F92EE;'>#聚合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80794, encryptionId=98bc80e9418, topicName=聚合物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bf611326764, createdName=yese, createdTime=Thu Jan 25 13:32:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281410, encodeId=c74b28141005, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Jan 24 00:05:56 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281392, encodeId=98bc281392e0, content=很好的文章.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Jan 23 23:24:45 CST 2018, time=2018-01-23, status=1, ipAttribution=)]
    2018-01-24 飛歌

    学习了很有用不错

    0

  10. 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encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Nov 01 18:32:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283905, encodeId=eada2839056a, content=学习., beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcVAydhtcpjiaxLrZD7Eb5YnKPgf7ypGpfyl7FflFyAenvQLbib6T0LPXIhXo9SPNPXYYFFJbEgykztwJ0HQ61I3F9GxIVKWsgQ/0, createdBy=f38d2052407, createdName=周周人, createdTime=Wed Jan 31 19:42:34 CST 2018, time=2018-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283551, encodeId=110d2835513f, content=学习啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], 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style='color:#2F92EE;'>#聚合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80794, encryptionId=98bc80e9418, topicName=聚合物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bf611326764, createdName=yese, createdTime=Thu Jan 25 13:32:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281410, encodeId=c74b28141005, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Jan 24 00:05:56 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281392, encodeId=98bc281392e0, content=很好的文章.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Jan 23 23:24:45 CST 2018, time=2018-01-23, status=1, ipAttribution=)]
    2018-01-23 清风拂面

    很好的文章.学习受益匪浅

    0

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