Am J Gastroenterol:非复杂急性憩室炎患者无需接受抗生素治疗

2018-04-27 zhangfan MedSci原创

研究认为,对于新发非复杂急性憩室炎患者,观察或抗生素治疗对患者长期预后影响差异不显著

非复杂急性憩室炎通常也采用抗生素治疗,但这一方案缺乏有效证据。近期的2个临床研究表明,对于非复杂急性憩室炎是否使用抗生素治疗对患者短期内复杂性、复发性憩室炎或乙状结肠切除术风险影响差异不显著。近日研究人员就新发非复杂急性憩室炎患者非抗生素治疗的长期效果进行了考察。

528名CT确诊的、新发、左侧非复杂急性憩室炎患者随机接受观察或抗生素治疗。24个月后考察患者复杂、复发性憩室炎或乙状结肠切除术率差异。

研究发现,是否接受抗生素治疗对新发非复杂急性憩室炎患者,憩室炎复发(观察组vs抗生素组,15.4% vs 14.9%)、复杂性进展(4.8 vs 3.3%)或接受乙状结肠切除术(9.0 vs 5.0%)影响不显著。50岁以下以及视觉模拟疼痛评分8分或以上患者其复发或复杂性憩室炎风险增加。多因素分析发现,治疗方法(是否使用抗生素)对复发或复杂性憩室炎风险无影响。

研究认为,对于新发非复杂急性憩室炎患者,观察或抗生素治疗对患者长期预后影响差异不显著。

原始出处:

S. T. van Dijk et al. Long-Term Effects of Omitting Antibiotics in Uncomplicated Acute Diverticulitis.Am J Gastroenterol. 27 April 2018.

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    2018-08-21 zhouqu_8
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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Wed May 02 05:16:42 CST 2018, time=2018-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310551, encodeId=af8c31055186, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Mon Apr 30 04:53:08 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310387, encodeId=7c6031038ebf, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55431, encryptionId=cd305543152, topicName=抗生素治疗)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/D2FD7704B41C9E22364B1E54ABB223BB/100, createdBy=1df22500220, createdName=ms1260584454294838, createdTime=Sun Apr 29 07:04:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391443, encodeId=cefd139144309, content=<a href='/topic/show?id=b5be53e91fc' target=_blank style='color:#2F92EE;'>#憩室炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53791, encryptionId=b5be53e91fc, topicName=憩室炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d4902500082, createdName=1249883fm12暂无昵称, createdTime=Sun Apr 29 07:04:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522726, encodeId=690a1522e26a8, content=<a href='/topic/show?id=14d853e8918' target=_blank style='color:#2F92EE;'>#憩室#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53789, encryptionId=14d853e8918, topicName=憩室)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=33b211483971, createdName=zutt, createdTime=Sun Apr 29 07:04:00 CST 2018, time=2018-04-29, status=1, ipAttribution=)]
    2018-05-02 秀红

    学习了

    0

  5. 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GetPortalCommentsPageByObjectIdResponse(id=1522726, encodeId=690a1522e26a8, content=<a href='/topic/show?id=14d853e8918' target=_blank style='color:#2F92EE;'>#憩室#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53789, encryptionId=14d853e8918, topicName=憩室)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=33b211483971, createdName=zutt, createdTime=Sun Apr 29 07:04:00 CST 2018, time=2018-04-29, status=1, ipAttribution=)]
    2018-04-30 yfjms

    学习

    0

  6. 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GetPortalCommentsPageByObjectIdResponse(id=1522726, encodeId=690a1522e26a8, content=<a href='/topic/show?id=14d853e8918' target=_blank style='color:#2F92EE;'>#憩室#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53789, encryptionId=14d853e8918, topicName=憩室)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=33b211483971, createdName=zutt, createdTime=Sun Apr 29 07:04:00 CST 2018, time=2018-04-29, status=1, ipAttribution=)]
    2018-04-29 cscdliu

    学习了.谢谢

    0

  7. 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    2018-04-29 cscdliu

    学习了.谢谢

    0

  8. 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    2018-04-29 zutt