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Molecules：盐酸米诺环素负载原位立方液晶可用于治疗牙周炎

2018-09-13 MedSci MedSci原创

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在本研究中，研究人员开发了一种可注射的原位液晶制剂，用于局部递送米诺环素盐酸盐（MH）治疗慢性牙周炎。 研究了原位液晶的理化性质、相结构、体外药物释放和药效学。结果显示，装有20mg/g MH的最佳制剂（植烷三醇（PT）/丙二醇（PG）/水，63/27/10，w/w/ w）是可注射的。前体制剂可以在6.97±0.10s的过量水中形成立方相凝胶。体外药物释放的结果表明，MH可持续释放4天。与模

在本研究中，研究人员开发了一种可注射的原位液晶制剂，用于局部递送米诺环素盐酸盐（MH）治疗慢性牙周炎。

研究了原位液晶的理化性质、相结构、体外药物释放和药效学。结果显示，装有20mg/g MH的最佳制剂（植烷三醇（PT）/丙二醇（PG）/水，63/27/10，w/w/ w）是可注射的。前体制剂可以在6.97±0.10s的过量水中形成立方相凝胶。体外药物释放的结果表明，MH可持续释放4天。与模型组相比，液晶前体制剂显著降低了牙龈指数，探诊深度和牙槽骨丧失（p <0.01）。此外，模型大鼠的病理特征也得到了改善。

结果表明，MH负载的原位立方液晶具有持续释放能力，可改善牙周临床症状。研究所开发的原位立方液晶可以是用于牙周疾病的MH局部递送的潜在载体。

原始出处：

Yang Z, Liang X, et al., Development and Evaluation of Minocycline Hydrochloride-Loaded In Situ Cubic Liquid Crystal for Intra-Periodontal Pocket Administration. Molecules. 2018 Sep 6;23(9). pii: E2275. doi: 10.3390/molecules23092275.

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    2018-09-18 SSRIs

    很好的研究

    0

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    2018-09-17 Jackie Li

    学习

    0

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    2018-09-17 SSRIs

    很好的学习机会

    0

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    2018-09-15 一天没事干

    很好的学习机会

    0

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    2018-09-14 ms5880526374914242

    #米诺环素#

    0

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    2018-09-14 医者仁心

    #牙周#

    0

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    2018-09-13 明月清辉

    谢谢分享，学习了

    0

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    2018-09-13 liumin1987

    嗯嗯，学习了。

    0

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    2018-09-13 飛歌

    厉害了这样也行啊

    0