J Clin Periodontol:种植体周围病变与黏膜下微生物失调的关系

2018-12-27 MedSci MedSci原创

本研究旨在分析不同程度的种植体周围炎(PI)病变的粘膜下微生物组。

本研究旨在分析不同程度的种植体周围炎(PI)病变的粘膜下微生物组。

材料和方法:通过16s测序评估30名患有未治疗的PI病变的非吸烟,系统健康受试者的45个粘膜下菌斑样本的微生物特征。在校正年龄,性别和每个受试者的多个样本后,使用线性混合模型通过探诊深度来鉴定具有不同丰度的分类群。进行网络分析以识别具有相互发生或排除的分类群。随后,使用微生物生态失调指数计算种植体周围探诊深度对粘膜下微生物生态失调的影响。

结果:PI的粘膜下微生物组中鉴定了337种不同的分类群。 12个分类群的总丰度与探诊深度的增加显着相关; 16个分类群发现了探诊深度较低的显着关系。网络分析确定了两个相互排斥的复合体,分别与浅牙周袋和深牙周袋相关。更深的种植体周围牙周袋与生态失调的显着增加有关。

种植体周围牙周袋深度的增加与粘膜下微生物组的显着变化和生态失调水平的增加相关。

原始出处:

Annika Kroger,et al.The severity of human peri‐implantitis lesions correlates with the level of submucosal microbial dysbiosis.Journal of  Clinical Periodontology.2018 Decemember. Doi:10.1111/jcpe.13023

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    2019-05-17 huangdf
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    2019-04-22 feather89
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    2018-12-29 snowpeakxu