J Periodont Res:牙周洁治后辅助使用甲硝唑有用吗?

2015-04-27 sunshine 译 MedSci原创

J Periodont Res:牙周洁治后辅助使用甲硝唑有用吗?关键词:牙周辅助性治疗   甲硝唑  牙周炎  吸烟慢性牙周炎患者的牙周治疗程序中,甲硝唑是否可作为一种辅助治疗措施的有效证据并不充分。该项试验的目的是为了评估甲硝唑(凝胶用于局部应用,药片用于系统治疗)作为一种慢性牙周炎吸烟患者全口牙周洁治(超声洁治去除牙结石/牙菌斑)后的辅助性治疗的效果。研



慢性牙周炎患者的牙周治疗程序中,甲硝唑是否可作为一种辅助治疗措施的有效证据并不充分。该项试验的目的是为了评估甲硝唑(凝胶用于局部应用,药片用于系统治疗)作为一种慢性牙周炎吸烟患者全口牙周洁治(超声洁治去除牙结石/牙菌斑)后的辅助性治疗的效果。

研究纳入30名慢性牙周炎吸烟患者,研究对象至少有6颗牙存在≥5mm的临床牙周附着丧失,并且牙周探诊深度(PPD)≥5mm。试验分三个小组,将这些研究对象随机分配到其中各个小组中(n=10)。
第一组:安慰剂凝胶每日3g局部应用(装有安慰剂凝胶的牙科托盘戴用整晚)+牙周洁治;第二组:15%的甲硝唑凝胶每日3g局部应用(装有15%甲硝唑凝胶的牙科托盘戴用整晚)+牙周洁治;第三组:每日单剂量750mg甲硝唑(灭滴灵)+牙周洁治。

牙周洁治术后,在基线和治疗第1个月,第3个月和第6个月时,对伴放线放线杆菌,牙龈卟啉单胞菌,福赛坦氏菌进行定量分析(通过实时聚合酶链反应),测定一些临床参数。这些临床参数包括,可见菌斑指数,牙龈出血指数【年】,相对附着水平和PPD。

结果发现,各组间在基线上的平均GBI和可见菌斑指数值并没有明显统计学差异(P≥0.05)。各组间所测得的所有临床参数也没用明显统计学差异(P>=0.05)。在第3和第6 个月时,各组均可观察到GBI的明显下降(P<0.05)。在第1,3和6 个月 时,各组均可以观察到PPD和相关附着水平的明显下降(P<0.05)。在第7和第30 天时,各组均可观察到细菌水平的明显下降(P<0.05)。

总而言之,慢性牙周炎患者牙周洁治后连续使用甲硝唑(凝胶或片剂)6个月与牙周洁治后连续使用安慰剂六个月相比,具有相似的临床和微生物学改善。因此,需要进一步的研究来证实这些研究结果的临床意义。

原始出处:

Bergamaschi CC, Santamaria MP, Berto LA, Cogo-Müller K, Motta RH, Salum EA, Nociti FH Júnior, Goodson JM, Groppo FC.Full mouth periodontal debridement with or without adjunctive metronidazole gel in smoking patients with chronic periodontitis: A pilot study.J Periodontal Res. 2015 Apr 21. doi: 10.1111/jre.12278.

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    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

    0

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    2015-12-06 feather89
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    2015-04-29 whmdzju
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    2015-04-28 chenhui888

    有意义

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=125347, encodeId=889112534e89, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 14:28:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725817, encodeId=f68e1e25817ff, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Dec 06 23:41:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299280, encodeId=35bf12992806c, content=<a href='/topic/show?id=5413699307e' target=_blank style='color:#2F92EE;'>#甲硝唑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69930, encryptionId=5413699307e, topicName=甲硝唑)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3860283, createdName=whmdzju, createdTime=Wed Apr 29 14:41:00 CST 2015, time=2015-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450406, encodeId=1fa51450406c3, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Wed Apr 29 14:41:00 CST 2015, time=2015-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22192, encodeId=4c852219271, content=有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=chenhui888, createdTime=Tue Apr 28 15:22:00 CST 2015, time=2015-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22190, encodeId=488b22190f5, content=这个研究不错!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=yydlt, createdTime=Tue Apr 28 14:27:00 CST 2015, time=2015-04-28, status=1, ipAttribution=)]
    2015-04-28 yydlt

    这个研究不错!

    0

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