Gastroenterology: 减少碳水化合物的摄入可以减少肠易激综合征的症状

2017-10-16 xuyihan MedSci原创

据报道,一些肠易激综合征(IBS)患者减少碳水化合物(FODMAP)的摄入可以减少肠易激综合征的症状,本项研究进行了一项RCT实验验证了此设想。

背景:据报道,一些肠易激综合征(IBS)患者减少碳水化合物的摄入可以减少肠易激综合征的症状,本项研究进行了一项RCT实验验证了此设想。

方法:根据罗马III标准在英国的2家医院筛选了104例IBS(18-65岁)患者,患者随机分配至观察组和对照组,予以低碳水化合物饮食以及安慰剂治疗,(27例接受假饮食/安慰剂,26次接受假饮食/益生菌,24种接受低FODMAP饮食/安慰剂,27种接受低FODMAP饮食/益生菌),在实验期间每天测量胃肠道症状和总体症状的发生率和严重程度以及粪便频率,并通过定量PCR和16S rRNA测序进行分析,主要终点是4周时测量缓解症状和粪便双歧杆菌量。

结果:低碳水化合物饮食组的患者比对照组有更高的临床缓解率(57%vs38%)尽管无统计学差异(P=0.051),低FODMAP饮食患者的总平均IBS严重程度评分系统评分(173±95)明显低于假饮食(224±89)(P =0.042),但是低FODMAP饮食对粪便样本中的微生物多样性没有影响。

结论:在IBS患者中低碳水化合物饮食可以减少其症状的发生率,与安慰剂相比,他并不能减少肠道粪菌多样性。

原始出处:

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    2017-11-27 许安
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CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253335, encodeId=62de253335f5, content=学习啦!谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Mon Oct 16 07:38:25 CST 2017, time=2017-10-16, status=1, ipAttribution=)]
    2017-10-23 lou.minghong

    学习了谢谢分享!

    0

  6. 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time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504330, encodeId=eab6150433072, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Oct 17 22:13:00 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253586, encodeId=3599253586f1, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Oct 17 06:45:31 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253335, encodeId=62de253335f5, content=学习啦!谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Mon Oct 16 07:38:25 CST 2017, time=2017-10-16, status=1, ipAttribution=)]
    2017-10-17 yuanming9
  8. 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  9. 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time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504330, encodeId=eab6150433072, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Oct 17 22:13:00 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253586, encodeId=3599253586f1, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Oct 17 06:45:31 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253335, encodeId=62de253335f5, content=学习啦!谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Mon Oct 16 07:38:25 CST 2017, time=2017-10-16, status=1, ipAttribution=)]
    2017-10-17 1dd8c52fm63(暂无匿称)

    学习学习.了解了解

    0

  10. 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time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504330, encodeId=eab6150433072, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Oct 17 22:13:00 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253586, encodeId=3599253586f1, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Oct 17 06:45:31 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253335, encodeId=62de253335f5, content=学习啦!谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Mon Oct 16 07:38:25 CST 2017, time=2017-10-16, status=1, ipAttribution=)]
    2017-10-16 tanxingdoctor

    学习啦!谢谢分享

    0