JCEM:代谢综合征与骨折风险降低有关

2013-07-03 desperado-c dxy

代谢综合征患者的骨折风险尚不明确。为了评估代谢综合征、骨折风险和骨矿密度(BMD)的关系,来自那不勒斯第二大学的Katherine Esposito教授及其团队进行了一项研究,该研究发现代谢综合征与骨折风险降低有关。该研究结果在线发表在2013年6月17日的《临床内分泌代谢杂志》(The journal of clinical endocrinology and metabolism)上。该研究搜

代谢综合征患者的骨折风险尚不明确。为了评估代谢综合征、骨折风险和骨矿密度(BMD)的关系,来自那不勒斯第二大学的Katherine Esposito教授及其团队进行了一项研究,该研究发现代谢综合征与骨折风险降低有关。该研究结果在线发表在2013年6月17日的《临床内分泌代谢杂志》(The journal of clinical endocrinology and metabolism)上。
该研究搜索了2012年12月以前的电子数据库(Medline、Scopus、美国科学情报研究所的数据库平台),并在不同站点的搜索报告中确定人类骨折和BMD的研究。有两个独立的评审员收集相关的报告。进行随机效应荟萃分析确定骨折风险和BMD值与代谢综合征的关系。
该研究结果包括17项研究的共35个数据集。在包括1350例骨折和1628例再发骨折的10篇文章(14个数据集)中,代谢综合征与骨折风险降低有关(风险比=0.85,95%可信区间=0.71至1.00;高异质性:I2=55%,P=0.006)。忽略2项极端研究的结果,代谢综合征与骨折风险呈显著负相关(RR=0.85,P=0.12;I2=34%,P=0.130)。大部分的骨折风险降低是在队列研究中观察到的(风险降低18%),暗示存在因果关系;性别、骨折点、以及代谢综合征的定义并不影响评估结果。在包括29341例受试者的16篇文章中,在有和没有代谢综合征的受试者之间,脊柱、股骨颈、或跟骨BMD值没有区别:平均差范围从0.001至0.012g/cm2(P>0.10)。
该研究发现,本文显示代谢综合征与骨折风险降低相关,且不伴有BMD的改变。这些发现的临床意义仍不确定,应在今后的前瞻性研究中解决。

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    2013-12-27 achengzhao
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    2013-07-15 smallant2015
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在慢性肾脏疾病(CKD)患者中维生素D缺乏非常常见。目前指南推荐的治疗策略在这类患者中与普通人群相似,然而,在CKD患者,维生素D充足的营养状态是否能预防PTH水平的增加仍不清楚。为了研究循环PTH与25(OH)D水平的关系,寻找PTH显著增加相关的25(OH)D阈值,来自法国巴黎第十一大学的Marie Metzger教授及其团队进行了一项研究,该研究发现在CKD患者,25(OH)D水平高于20n