Biomed Res Int:颌骨药物相关性骨坏死风险患者的牙科管理

2018-10-15 MedSci MedSci原创

与药物相关的颌骨坏死(MRONJ)是抗吸收和抗血管生成剂的严重不良反应,这是一种潜在的痛苦和衰弱的疾病,大大影响患者的生活质量。此外,即使其流行病学和发病机制尚未完全阐明,在预防方案中也已认识到与MRONJ相关的几个风险因素。三个主要风险因素如下:(i)ONJ相关药物的类型:抗吸收(例如,双膦酸盐,Denosumab)和抗血管生成药物(例如贝伐单抗,舒尼替尼);(ii)MRONJ患者的类别风险:癌

与药物相关的颌骨坏死(MRONJ)是抗吸收和抗血管生成剂的严重不良反应,这是一种潜在的痛苦和衰弱的疾病,大大影响患者的生活质量。此外,即使其流行病学和发病机制尚未完全阐明,在预防方案中也已认识到与MRONJ相关的几个风险因素。

三个主要风险因素如下:(i)ONJ相关药物的类型:抗吸收(例如,双膦酸盐,Denosumab)和抗血管生成药物(例如贝伐单抗,舒尼替尼);(ii)MRONJ患者的类别风险:癌症与非癌症患者;(iii)牙科治疗的类型和时间(例如,在药物治疗之前,期间或之后)。本文旨在描述意大利口腔病理学和医学学会(SIPMO)在上述ONJ相关药物给药之前和期间/之后对MRONJ风险患者进行预防性牙科治疗的新范例。

在降低MRONJ的风险方面,牙医和口腔卫生师是为治疗前和治疗中的患者应用正确的一级预防方案的关键人物。然而,应始终采用多学科标准化方法的必要性,并在所涉专家之间进行持续对话,以提高预防策略的效果并改善患者的生活质量。

原始出处:

Olga Di Fede, Vera Panzarella, et al., The Dental Management of Patients at Risk of Medication-Related Osteonecrosis of the Jaw: New Paradigm of Primary Prevention. Biomed Res Int. 2018; 2018: 2684924.

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    2019-09-03 zll0634
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    2018-11-25 sunylz
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    2018-10-17 millore
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    2018-10-17 xzw115
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