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Virus Res：奎宁可作为抗登革热病毒感染治疗药物

2018-08-07 木木 病毒学界

奎宁登革热新药
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近日，来自泰国的科学家发现，奎宁具有治疗登革热病毒感染的作用，该研究结果目前已发表至《Virus Research》杂志

登革热病毒是属于黄热病毒属的小型黄病毒，能够引起登革出血热/登革休克综合征，通常以白纹伊蚊和埃及伊蚊为主要的传播媒介，在全球的60多个国家和地区广泛流行。据统计，每年受感染的人群超过1亿，超过20亿以上的人存在感染的威胁。目前，该病毒的感染还没有比较好的治疗药物。近日，来自泰国的科学家发现，奎宁具有治疗登革热病毒感染的作用，该研究结果目前已发表至《Virus Research》杂志，题为“Drug repurposing of quinine as antiviral against dengue virus infection”

1、研究人员通过将奎宁作用与登革热病毒感染的人源细胞，发现奎宁对4种不同血清型的登革热病毒都有抑制作用，且抑制率能达到80%。



2、研究人员通过研究奎宁对登革热病毒的抑制机理发现，奎宁可通过直接减少登革热病毒RNA和蛋白质的合成来抑制病毒的增殖，通过奎宁还可以激发机体的先天免疫反应来对抗病毒。



这些研究结果证实奎宁可有效的抑制登革热病毒的增殖并激发机体的先天免疫反应，说明奎宁可以作为治疗登革热的新药的开发。

原始出处：Malakar S1, Sreelatha L2, Dechtawewat T3, et al. Drug repurposing of quinine as antiviral against dengue virus infection. Virus Res. 2018 Jul 25.

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    2018-12-18 周虎

    #治疗药物#

    0

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    2019-07-20 shuangle

    #登革热病毒#

    0

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    2019-02-23 ms5187542471278033

    #登革热病#

    0

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    2018-08-09 sunrural_42825361

    #virus#

    0

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    2018-08-07 hilda0308

    登革热是否改名为基孔肯亚热？

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1921717, encodeId=7ab01921e173d, content=<a href='/topic/show?id=4f0a6469837' target=_blank style='color:#2F92EE;'>#治疗药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64698, encryptionId=4f0a6469837, topicName=治疗药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9d3459, createdName=周虎, createdTime=Tue Dec 18 07:37:00 CST 2018, time=2018-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1975910, encodeId=d39d19e591088, content=<a href='/topic/show?id=f541e160854' target=_blank style='color:#2F92EE;'>#登革热病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71608, encryptionId=f541e160854, topicName=登革热病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=shuangle, createdTime=Sat Jul 20 01:37:00 CST 2019, time=2019-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1764399, encodeId=e6ad1e64399ea, content=<a href='/topic/show?id=0ca1e160642' target=_blank style='color:#2F92EE;'>#登革热病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71606, encryptionId=0ca1e160642, topicName=登革热病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7f7537733227, createdName=ms5187542471278033, createdTime=Sat Feb 23 17:37:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541672, encodeId=930c15416e293, content=<a href='/topic/show?id=fe9c18456c2' target=_blank style='color:#2F92EE;'>#virus#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18456, encryptionId=fe9c18456c2, topicName=virus)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=823413309323, createdName=sunrural_42825361, createdTime=Thu Aug 09 02:37:00 CST 2018, time=2018-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=337141, encodeId=119033e14180, content=登革热是否改名为基孔肯亚热？, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/08/07/d2326394f79ffdaa0cf4b522a9c39d3b.jpg, createdBy=44a42323233, createdName=hilda0308, createdTime=Tue Aug 07 17:47:32 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=337051, encodeId=af9833e051d1, content=感谢小编为我们准备了如此丰盛的精神大餐，同时也向作者致谢！认真学习了，点赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Aug 07 12:53:49 CST 2018, time=2018-08-07, status=1, ipAttribution=)]
    2018-08-07 ylzr123

    感谢小编为我们准备了如此丰盛的精神大餐，同时也向作者致谢！认真学习了，点赞！

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