J Gastroen Hepatol:警惕溃疡性结肠炎患者肛周疾病风险

2019-07-02 MedSci MedSci原创

研究认为溃疡性结肠炎并发肛周疾病风险增加

溃疡性结肠炎(UC)患者肛周疾病(PAD)的风险和临床影响尚未被完全评估。近日研究人员调查了UC患者PAD的发病率,并根据PAD的存在情况比较了UC的临床特点和预后。

研究在韩国开展,考察2010-14年间韩国国家健康保险理赔数据库数据,评价了在基于人群和基于医院的队列中UC伴PAD患者的临床特征和结果。

在基于人群的队列中,UC患者中PAD的发生率和标准化发生率分别为3.74/1000人-年和2.88。在基于医院的队列中,诊断后1年、5年、10年和20年PAD的累积概率分别为1.0%、2.3%、4.0%和6.3%。在基于人群和医院的队列中,患有PAD的UC患者在诊断时显示了更高比例的皮质类固醇使用和广泛性结肠炎特征。配对分析显示,PAD患者接受抗肿瘤坏死因子药物治疗和结肠切除术风险显著高于非PAD患者。

研究认为溃疡性结肠炎并发肛周疾病风险增加。

原始出处:


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    2020-03-02 nymo
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    2019-08-25 许安
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    2019-07-04 gwc384
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    2019-07-02 百草

    666

    0

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