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Hypertension：血管周围脂肪组织血管紧张素II1型受体促进血管炎症和动脉瘤的形成

2017-08-05 MedSci MedSci原创

血管紧张素II1型受体血管炎症动脉瘤
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血管周围的脂肪组织具有活动性局部炎症的特征，这一特征有助于肥胖/代谢综合征的并发症动脉粥样硬化疾病的发展。然而，血管周围脂肪组织在腹主动脉瘤进展中的确切作用尚不清楚。近期，一项发表在杂志Hypertension上的研究探讨了血管紧张素内皮脂肪组织（VAT）中血管紧张素II型1a（AT1a）受体的遗传性缺失是否可以减轻载脂蛋白E缺陷型（ApoE-/- ）小鼠主动脉瘤的形成。研究者们使用血管紧张素II

血管周围的脂肪组织具有活动性局部炎症的特征，这一特征有助于肥胖/代谢综合征的并发症动脉粥样硬化疾病的发展。然而，血管周围脂肪组织在腹主动脉瘤进展中的确切作用尚不清楚。近期，一项发表在杂志Hypertension上的研究探讨了血管紧张素内皮脂肪组织（VAT）中血管紧张素II型1a（AT1a）受体的遗传性缺失是否可以减轻载脂蛋白E缺陷型（ApoE-/- ）小鼠主动脉瘤的形成。研究者们使用血管紧张素II诱导的动脉瘤小鼠模型，将ApoE-/- 或ApoE-/- AT1a-/- 供体小鼠移植到ApoE-/-受体小鼠的腹主动脉上。与ApoE-/-VAT移植相比，ApoE-/- AT1a-/-VAT移植显着减弱了腹主动脉主动脉瘤的形成，巨噬细胞的浸润和明胶溶解的活性。AT1a受体激活导致巨噬细胞在血管周围VAT中的极化并朝向促炎表型的发展。此外，ApoE-/- AT1a-/-血管周围血管增生素的骨桥蛋白表达和明胶溶解活性明显低于ApoE-/- 血管周围的VAT，而在脂肪细胞缺失AT1a受体后，血管紧张素II诱导的脂肪细胞骨桥蛋白分泌的作用被消除。另一项值得注意的结果显示，通过用骨桥蛋白中和抗体治疗可

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    2018-02-03 feather89

    #PE#

    0

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    2017-11-25 12498ebem19暂无昵称

    #TENS#

    0

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    2017-08-07 shijzhiewnjhch

    #血管炎#

    0

  4. 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createdName=执着追梦, createdTime=Sun Aug 06 07:16:33 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230408, encodeId=89ce230408a4, content=好好学习下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Aug 05 18:23:52 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-07 yige2004

    #脂肪组织#

    0

  5. 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createdName=执着追梦, createdTime=Sun Aug 06 07:16:33 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230408, encodeId=89ce230408a4, content=好好学习下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Aug 05 18:23:52 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-07 ms6832696159214430

    #血管炎症#

    0

  6. 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GetPortalCommentsPageByObjectIdResponse(id=1589301, encodeId=bf311589301f0, content=<a href='/topic/show?id=fb0389e4373' target=_blank style='color:#2F92EE;'>#血管紧张素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89743, encryptionId=fb0389e4373, topicName=血管紧张素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5ce517702394, createdName=xiongliangxl, createdTime=Mon Aug 07 04:01:00 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230585, encodeId=44b5230585b6, content=学习，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Sun Aug 06 07:16:33 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230408, encodeId=89ce230408a4, content=好好学习下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Aug 05 18:23:52 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-07 jambiya

    #Hypertension#

    0

  7. 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createdName=执着追梦, createdTime=Sun Aug 06 07:16:33 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230408, encodeId=89ce230408a4, content=好好学习下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Aug 05 18:23:52 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-07 bbwznl

    #血管紧张素II#

    0

  8. 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createdName=执着追梦, createdTime=Sun Aug 06 07:16:33 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230408, encodeId=89ce230408a4, content=好好学习下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Aug 05 18:23:52 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-07 xiongliangxl

    #血管紧张素#

    0

  9. 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createdName=执着追梦, createdTime=Sun Aug 06 07:16:33 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230408, encodeId=89ce230408a4, content=好好学习下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Aug 05 18:23:52 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-06 执着追梦

    学习，谢谢分享

    0

  10. 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createdName=执着追梦, createdTime=Sun Aug 06 07:16:33 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230408, encodeId=89ce230408a4, content=好好学习下吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Aug 05 18:23:52 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-05 忠诚向上

    好好学习下吧

    0

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