Environ Health Perspect:空气污染真能导致动脉粥样硬化?

2015-01-30 MedSci MedSci原创

在4个欧洲国家,我们横向比较了长期暴露于空气污染与颈动脉内膜中层厚度(CIMT,动脉粥样硬化临床前标记)之间的联系。 在European Study of Cohorts for Air Pollution effects-ESCAPE study草案中,我们记录了来自斯德哥尔摩(瑞典),Ausburg和鲁尔地区(德国)和赫区域(西班牙)四个地区的NO2, NOx, PM2.5, PM10,PM

在4个欧洲国家,我们横向比较了长期暴露于空气污染与颈动脉内膜中层厚度(CIMT,动脉粥样硬化临床前标记)之间的联系。

在European Study of Cohorts for Air Pollution effects-ESCAPE study草案中,我们记录了来自斯德哥尔摩(瑞典),Ausburg和鲁尔地区(德国)和赫区域(西班牙)四个地区的NO2, NOx, PM2.5, PM10,PMcoarse和靠近交通拥堵道路旁空气暴漏的标准水平。在这项研究中,我们使用线性回归和meta分析分析了长期暴露于空气污染与颈动脉内膜中层厚度(CIMT)之间的联系。

研究收纳并分析了9183人,结果显示了在PM2.5(颗粒物直径< 2.5μm)每5μg/m颈动脉内膜中层厚度(CIMT)增加(几何平均数)0.72%(95% CI:-0.65%, 2.10%),在PM2.5abs每10-5/m颈动脉内膜中层厚度(CIMT)增加0.42%(95% CI: -0.46%, 1.30%),住在交通拥堵的道路旁对CIMT有积极影响但无明显相关性。然而,对于一些其他污染物和颈动脉内膜中层厚度(CIMT)无明显相关性。在调整不同的设置和敏感性分析中也得到了相同的结果。在另外扩展的三个先前发表的研究结果中,在PM2.5每5μg/m3颈动脉内膜中层厚度(CIMT)增加0.78% (95% CI: -0.18%, 1.75%)。

我们横向比较了4个欧洲国家长期暴露于空气污染与颈动脉内膜中层厚度(CIMT)之间的联系,最终得出结论,空气污染和动脉粥样硬化没有统计学意义,另外扩展的三个先前发表的研究结果中CIMT和PM2.5也无相关性。

原始出处

Perez L1, Wolf K, Hennig F, Penell J, Basaga?a X, Aguilera I, Agis D, Beelen R, Brunekreef B, Cyrys J, Fuks KB, Adam M, Baldassare D, Cirach M, Elosua R, Dratva J, Hampel R, Koenig W, Marrugat J, De Faire U, Pershagen G, Probst-Hensch NM, de Nazelle A, Nieuwenhuijsen MJ, Rathmann W, Rivera M, Seissler J, Schindler C, Thierry J, Hoffmann B, Peters A, Künzli N.Air Pollution and Atherosclerosis: A Cross-Sectional Analysis of Four European Cohort Studies in the ESCAPE Study.Environ Health Perspect. 2015 Jan 27.

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    2015-06-22 feather89
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    2015-02-17 chinayinhan

    已阅

    0

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    2015-09-25 hb2008ye
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    2015-07-26 shizhenshan
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    2015-02-01 july_979
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2014年5月30日,由陈桢玥教授,梁春教授主持,荆清教授主讲的“动脉粥样硬化相关科研基金申请的注意事项”在上海国际会议中心举行(OCC 2014大会)。本次讲座主要围绕着国家自然科学基金项目申请准备,撰写项目申请书及注意事项以及申请及评审程序这三个方面进行展开。 首先荆教授简略介绍了下各资助项目的类型资助额度以及资助年限,其中重点介绍了“血管稳态与重构的调控机制”这个项目,荆教授认为该项目资助

Nature review immunology:胆固醇炎症反应与动脉粥样硬化

进入工业化社会以来,人们的饮食发生了很大的改变。长期食用富含脂肪与固醇的食物使血液系统中富含胆固醇的低密度脂蛋白(LDL)含量增高,促进了胆固醇在动脉血管壁上的过量沉积,并且引起炎症反应,最终造成动脉粥样硬化。修饰后LDL作为一类细胞表面TLR的配体,本身可以触发先天性免疫反应,巨噬细胞受到修饰后LDL的刺激后会发生吞噬作用,从而造成了胆固醇在胞内的累积,而这一效应又会增强下一轮的免疫反应。另一方

PLoS Pathog:科学家揭示牙周炎和动脉粥样硬化潜在的分子关联

引起慢性口腔感染牙周疾病的病原体-牙龈卟啉单胞菌不仅可以引发牙龈的局部炎症,而且该病原菌还和动脉粥样硬化风险的增加直接相关,近日,刊登在国际杂志PLoS Pathogens上的一篇研究论文中,来自波士顿大学医学院的研究人员通过研究揭示了牙龈卟啉单胞菌入侵机体免疫系统诱导口腔炎症及其它疾病的分子机制。 牙龈卟啉单胞菌的细胞外层也包含着许多糖类和脂质,千百年来哺乳动物免疫系统已经进化到可以识别部分的

PLoS Pathog:牙周炎和动脉粥样硬化潜在的分子关联

引起慢性口腔感染牙周疾病的病原体-牙龈卟啉单胞菌不仅可以引发牙龈的局部炎症,而且该病原菌还和动脉粥样硬化风险的增加直接相关,近日,刊登在国际杂志PLoS Pathogens上的一篇研究论文中,来自波士顿大学医学院的研究人员通过研究揭示了牙龈卟啉单胞菌入侵机体免疫系统诱导口腔炎症及其它疾病的分子机制。 牙龈卟啉单胞菌的细胞外层也包含着许多糖类和脂质,千百年来哺乳动物免疫系统已经进化到可以识别部

Circul Res:科学家揭示动脉粥样硬化的发病机制

近日,一项发表在国际杂志Circulation Research上的研究报告中,来自图宾根大学等处的研究人员通过研究揭示了动脉粥样硬化患者机体血管平滑肌细胞一种被忽略的重要功能。动脉粥样硬化,也就是患者动脉壁上形成了斑块,在西方国家这种疾病会引发患者心肌梗塞、中风甚至死亡;这种疾病是机体动脉中可变的脂蛋白、多种单核细胞衍生的巨噬细胞以及平滑肌细胞相互作用而引起的是一种慢性炎性疾病,研究者表示

JACC:体重增加期间进食脂肪类型影响脂质谱

瑞典一项研究表明,体重增加期间进食多不饱和脂肪酸(PUFA)的个体致动脉粥样硬化脂蛋白降低,进食多饱和脂肪酸(SFA)者则升高。论文于10月15日在线发表于《美国心脏病学会杂志》。 此项为期7周的研究共纳入39例健康消瘦受试者,并通过进食约三个松饼的方式使受试者每日额外摄入750 kcal。除脂肪类型不同之外,松饼的制备方法均相同。19例受试者的进食的松饼由来自于葵花籽油的PUFA制成,其余20