Clin Endocrinol:健康女性中高泌乳素血症患病率低

2013-09-12 佚名 丁香园

特定人群无症状高泌乳素血症患病率被广泛研究,例如抗精神病药物使用者、不孕的女性或原发性甲状腺功能减退患者,但是文献中健康人群中高泌乳素血症和巨泌乳素血症患病率的数据非常罕见。为了公正的评估绝经前女性高泌乳素血糖的患病率及其病因,包括巨泌乳素血症和精神紧张相关的高泌乳素血症,同时考虑到激素类避孕药所致的高泌乳素血症,来自西班牙阿卡拉大学Hector F Escobar-Mor

特定人群无症状高泌乳素血症患病率被广泛研究,例如抗精神病药物使用者、不孕的女性或原发性甲状腺功能减退患者,但是文献中健康人群中高泌乳素血症和巨泌乳素血症患病率的数据非常罕见。

为了公正的评估绝经前女性高泌乳素血糖的患病率及其病因,包括巨泌乳素血症和精神紧张相关的高泌乳素血症,同时考虑到激素类避孕药所致的高泌乳素血症,来自西班牙阿卡拉大学Hector F Escobar-Morreale教授及其团队进行了一项研究,该研究发现健康女性供血者高泌乳素血症患病率低,并且不受使用激素类避孕药的影响。该研究结果在线发表在2013年10月的 Clinical Endocrinology 杂志上。【原文下载】

该研究是一项患病率调查,相继有393例绝经前女性受试者声称自愿供血。该研究进行详尽的病史采集和体格检查,以明确多毛、痤疮、脱发、月经失调和生育史的存在。同时测量血清泌乳素(PRL)(当需要时排除巨泌乳素血症)、促甲状腺急速、总睾酮、雄烯二酮、性激素结合球蛋白和硫酸脱氢表雄酮浓度。

该研究结果表明,393例女性中16例血清PRL浓度增加。总的女性供血人群中巨泌乳素血症患病率为0.6%,并且在高泌乳素患者中间巨泌乳素血症患病率为12.5%.其余的高泌乳素血症女性中精神紧张相关的高泌乳素血症为最可能的病因。最后,激素类避孕药使用者和非使用者的高泌乳素血症发生率相似。

该研究发现,健康女性供血者高泌乳素血症患病率低,并且不受使用激素类避孕药的影响。病因非常罕见,精神紧张相关性高泌乳素血症和巨泌乳素血症是这些女性高泌乳素血症最常见原因。

原文下载

Alpañés M, Sanchón R, Martínez-García MÁ, Martínez-Bermejo E, Escobar-Morreale HF.Prevalence of hyperprolactinaemia in female premenopausal blood donors.Clin Endocrinol (Oxf). 2013 Oct;79(4):545-9. doi: 10.1111/cen.12182. 

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