JAMA Oncol:子宫肌瘤切除术后潜在的癌症

2015-02-23 赵洲 MedSci原创

子宫肌瘤是子宫中的良性平滑肌瘤。这些肌瘤是很常见的,据估计20%-50%女性有子宫肌瘤。尽管子宫肌瘤通过是无症状的,但能造成疼痛、月经不调以及生育能力降低。子宫肌瘤切除术现在常常通过微创手术得以实现。电动分碎术,或者使用机械装置切除子宫肌瘤有可能被用于促进子宫肌瘤的切除。为了分析潜在的癌症和癌症前期变化的患病率,研究人员使用了美国国家数据库进行回顾性分析。数据是在2006年1月至2



子宫肌瘤是子宫中的良性平滑肌瘤。这些肌瘤是很常见的,据估计20%-50%女性有子宫肌瘤。尽管子宫肌瘤通过是无症状的,但能造成疼痛、月经不调以及生育能力降低。子宫肌瘤切除术现在常常通过微创手术得以实现。电动分碎术,或者使用机械装置切除子宫肌瘤有可能被用于促进子宫肌瘤的切除。为了分析潜在的癌症和癌症前期变化的患病率,研究人员使用了美国国家数据库进行回顾性分析。数据是在2006年1月至2012年12月间,496所医院中有子宫肌瘤女性所提供的。在当时,电动分碎术已经被研究了。对子宫癌、不确定性恶性肿瘤和子宫内膜增生的患病率进行估计。建立多变量的混合影响回归模型以检验电动分碎术使用的影响因素和与不良病理结果相关的因素。

本次试验共有样本数41777例,其中3220人(7.7%)接受电动分碎术切除子宫肌瘤。在不使用电动分碎术切除子宫肌瘤的患者中,有73人(0.19%,95%CI 0.15%-0.23%)罹患子宫癌;使用电动分碎术切除子宫肌瘤的患者中,有3人(0.09%,95%CI 0.02%-0.27%)罹患子宫癌。不确定性恶性肿瘤和子宫内膜增生相应的比例分别为0.67%(257人)和0.43%(14人)。子宫癌最严重的风险因素是高龄。

总言之,无论是否使用电动分碎术切除子宫肌瘤,癌症的患病率和癌症前期的子宫异常比例都是较低的。但是,研究表明随着年龄增加,风险相应地增大。因此,对高龄子宫肌妇女使用电动分碎术应当更为审慎。

原始出处:

Wright JD, Tergas AI, Cui R, et al. Use of Electric Power Morcellation and Prevalence of Underlying Cancer in Women Who Undergo Myomectomy. JAMA Oncol.Published online February 19, 2015. doi:10.1001/jamaoncol.2014.206.

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    2015-08-13 minlingfeng
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    2015-05-16 ljjj1053

    很不错学习了

    0

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    2015-02-27 xiaoai5777

    好文章,超赞

    0

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    2015-02-24 zhouanxiu

    感谢你们的辛勤付出

    0

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    2015-02-24 orthoW

    不错的文章,学习了

    0

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