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Mater Sci Eng C Mater Biol Appl：新型纳米纤维膜可快速促进皮肤伤口愈合，并可防止感染

2019-09-25 不详 网络

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皮肤伤口，特别是慢性伤口，仍然是临床上的挑战，这部分是由于复杂的愈合过程，该过程由四个重叠但截然不同的阶段组成，包括止血，炎症，增殖和重塑。因此，具有在空间上设计的结构的伤口敷料可以在时间上调节某些生物活性成分，使其在特定的愈合阶段起作用，从而能够加快愈合过程。在这项研究中，通过顺序电纺丝制备了掺入壳聚糖-PVA（聚乙烯醇）三层纳米纤维膜（nBG-TFM）的纳米生物玻璃。该膜表现出优异的生物相容性

皮肤伤口，特别是慢性伤口，仍然是临床上的挑战，这部分是由于复杂的愈合过程，该过程由四个重叠但截然不同的阶段组成，包括止血，炎症，增殖和重塑。因此，具有在空间上设计的结构的伤口敷料可以在时间上调节某些生物活性成分，使其在特定的愈合阶段起作用，从而能够加快愈合过程。

在这项研究中，通过顺序电纺丝制备了掺入壳聚糖-PVA（聚乙烯醇）三层纳米纤维膜（nBG-TFM）的纳米生物玻璃。该膜表现出优异的生物相容性，抗菌活性和促进再生的作用。此外，与均匀膜相比，空间设计的结构优化了每个组件的功能，并提供了更合适的微环境。大鼠全层皮肤缺损模型和小鼠糖尿病慢性伤口模型显示，nBG-TFM可以在完全重新上皮，改善胶原蛋白排列和形成皮肤附件方面实现明显的加速和增强的愈合。揭示了nBG-TFM通过上调包括VEGF和TGF-β的生长因子起作用。同时，炎性细胞因子例如TNF-α和IL-1β被下调。

总之，这项研究中提出的技术为设计可促进慢性伤口愈合的功能性伤口敷料提供了新的思路。

原始出处：

Chen Q, Wu J, et al., Electrospun chitosan/PVA/bioglass Nanofibrous membrane with spatially designed structure for accelerating chronic wound healing. Mater Sci Eng C Mater Biol Appl. 2019 Dec;105:110083. doi: 10.1016/j.msec.2019.110083. Epub 2019 Aug 13.

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    2020-03-17 12498ebem31暂无昵称

    #Biol#

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    2020-04-05 sunylz

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    2019-11-19 spoonycyy

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    2019-09-27 chenzhuanggui

    #伤口愈合#

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