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周兆才博士：靶向YAP的个体化胃癌治疗

2016-05-16 佚名 生物谷

靶向YAP胃癌个体化治疗
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2016年5月13日至14日，（第三届）肿瘤与免疫治疗研讨会在上海好望角大饭店隆重召开，上海生科院生物化学与细胞生物学研究所周兆才研究员向大家介绍了靶向YAP的个体化胃癌治疗，演讲十分精彩。 周兆才研究员表示，胃癌是全世界范围内死亡率仅次于肺癌的恶性肿瘤，并且中国是一个胃癌发生大国，而针对胃癌的有效治疗手段非常有限。Hippo信号通路是近年来研究越来越多的癌症相关信号通路，在肿瘤发生发展和治

2016年5月13日至14日，（第三届）肿瘤与免疫治疗研讨会在上海好望角大饭店隆重召开，上海生科院生物化学与细胞生物学研究所周兆才研究员向大家介绍了靶向YAP的个体化胃癌治疗，演讲十分精彩。

周兆才研究员表示，胃癌是全世界范围内死亡率仅次于肺癌的恶性肿瘤，并且中国是一个胃癌发生大国，而针对胃癌的有效治疗手段非常有限。Hippo信号通路是近年来研究越来越多的癌症相关信号通路，在肿瘤发生发展和治疗方面受到密切关注。YAP蛋白是Hippo通路的最下游信号分子，与TEADs形成“杂合”转录因子，从而调控一系列与生长相关的靶基因。众多临床分析发现，YAP在多种恶性肿瘤中表达明显上调，相对于针对Hippo信号通路的上游调节分子，靶向YAP的抑制剂可能会更有效和直接地纠正失调的信号通路，从而达到治疗肿瘤的目的。

周兆才研究员通过临床样品筛选、复合物蛋白质晶体结构解析等方法发现了一个YAP的天然拮抗蛋白VGLL4，并设计了与其类似的多肽抑制剂，可以与YAP竞争TEADs的结合位点。在体内和体外实验中证明这一VGLL4重组多肽对抑制YAP有效。今后周兆才研究员还将研究针对YAP的小分子化合物，和多肽相比，将具有更好的稳定性。这项研究为胃癌的治疗提供了一个新的思路和选择方案，也可以为其它具有YAP/VGLL4比例失调的恶性肿瘤提供个性化的治疗策略。

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    2017-04-04 ms3892185887221420

    #胃癌治疗#

    0

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    2017-02-11 gujh

    #YAP#

    0

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    2016-05-18 zhouqu_8

    #个体化#

    0

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    2016-05-17 stead

    有时候想关注详细点

    0

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    2016-05-17 stead

    还有希望有些课程全面点

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1763846, encodeId=b0d71e63846ee, content=<a href='/topic/show?id=d34b8324025' target=_blank style='color:#2F92EE;'>#胃癌治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83240, encryptionId=d34b8324025, topicName=胃癌治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d69837584753, createdName=ms3892185887221420, createdTime=Tue Apr 04 18:50:00 CST 2017, time=2017-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081882, encodeId=6a682081882f7, content=<a href='/topic/show?id=c2971893397' target=_blank style='color:#2F92EE;'>#YAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18933, encryptionId=c2971893397, topicName=YAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3333505, createdName=gujh, createdTime=Sat Feb 11 19:50:00 CST 2017, time=2017-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435324, encodeId=636214353247e, content=<a href='/topic/show?id=9a5c212e88f' target=_blank style='color:#2F92EE;'>#个体化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=21278, encryptionId=9a5c212e88f, topicName=个体化)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed May 18 04:50:00 CST 2016, time=2016-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86172, encodeId=7287861e2ed, content=有时候想关注详细点, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Tue May 17 18:30:00 CST 2016, time=2016-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86173, encodeId=9a8d861e363, content=还有希望有些课程全面点, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Tue May 17 18:30:00 CST 2016, time=2016-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86169, encodeId=b79786169ea, content=有点不理解，, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Tue May 17 18:29:00 CST 2016, time=2016-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86170, encodeId=08aa861e07d, content=为什么每责, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Tue May 17 18:29:00 CST 2016, time=2016-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86171, encodeId=06aa861e14f, content=有点短，不详细, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Tue May 17 18:29:00 CST 2016, time=2016-05-17, status=1, ipAttribution=)]
    2016-05-17 stead

    有点不理解，

    0

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    2016-05-17 stead

    为什么每责

    0

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    2016-05-17 stead

    有点短，不详细

    0