Mater Sci Eng C Mater Biol Appl:具有磁场的新型磁性磷酸钙 - 干细胞构建体增强成骨分化和骨组织工程

2019-03-06 不详 网络

超顺磁性氧化铁纳米粒子(IONP)是有前途的生物活性添加剂,用于制造骨组织工程的磁性支架。迄今为止,还没有关于使用外部静磁场(SMF)的IONP掺入的磷酸钙骨水泥(IONP-CPC)支架在干细胞上的骨诱导性的报道。本研究旨在:(1)开发用于骨组织工程的新型磁性IONP-CPC构建体,和(2)研究IONP掺入和SMF应用对人体增殖,成骨分化和骨矿物质合成的影响。将牙髓干细胞(hDPSCs)首次接种于

超顺磁性氧化铁纳米粒子(IONP)是有前途的生物活性添加剂,用于制造骨组织工程的磁性支架。迄今为止,还没有关于使用外部静磁场(SMF)的IONP掺入的磷酸钙骨水泥(IONP-CPC)支架在干细胞上的骨诱导性的报道。本研究旨在:(1)开发用于骨组织工程的新型磁性IONP-CPC构建体,和(2)研究IONP掺入和SMF应用对人体增殖,成骨分化和骨矿物质合成的影响。

将牙髓干细胞(hDPSCs)首次接种于IONP-CPC支架上。SMF下的新型磁性IONP-CPC增强了hDPSCs的细胞性能,产生了更大的碱性磷酸酶活性(约3倍),成骨标记基因的表达增加,以及更多的细胞合成骨矿物质(约2.5倍),CPC控制和非磁性IONP-CPC。此外,IONP-CPC在大鼠下颌骨缺损中诱导比CPC控制更活跃的成骨。这些结果与SMF下介质中磁性IONP增强的细胞性能一致。此外,通过透射电子显微镜(TEM)在细胞内检测纳米聚集体。

因此,增强的细胞性能归因于磁场产生的物理力以及来自IONP-CPC构建体的释放的磁性纳米颗粒的细胞内化。

原始出处:

Xia Y, Chen H, et al., Novel magnetic calcium phosphate-stem cell construct with magnetic field enhances osteogenic differentiation and bone tissue engineering. Mater Sci Eng C Mater Biol Appl. 2019 May;98:30-41. doi: 10.1016/j.msec.2018.12.120. Epub 2018 Dec 28.

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    2019-10-23 1254a331m32暂无昵称

    学习一下

    0

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    2020-01-13 spoonycyy
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1767617, encodeId=c1511e67617b2, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Fri May 10 18:28:00 CST 2019, time=2019-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=374290, encodeId=13633e4290d0, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Wed Oct 23 11:32:26 CST 2019, time=2019-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081537, encodeId=9a89208153e2d, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Mon Jan 13 22:28:00 CST 2020, time=2020-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070090, encodeId=105d20e009069, content=<a href='/topic/show?id=9ced1018209a' target=_blank style='color:#2F92EE;'>#骨组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101820, encryptionId=9ced1018209a, topicName=骨组织工程)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Mon Feb 17 06:28:00 CST 2020, time=2020-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076356, encodeId=408520e6356a5, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Fri Feb 07 21:28:00 CST 2020, time=2020-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918567, encodeId=418c191856e72, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Jan 23 12:28:00 CST 2020, time=2020-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368928, encodeId=bd7536892885, content=加油(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Wed Jul 03 20:06:09 CST 2019, time=2019-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368072, encodeId=d3743680e2a1, content=加油(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Thu Jun 20 19:54:04 CST 2019, time=2019-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366394, encodeId=19cb366394d6, content=学习了!(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Sat May 18 12:23:35 CST 2019, time=2019-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365267, encodeId=00d836526eab, content=加油(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Thu Apr 25 23:54:05 CST 2019, time=2019-04-25, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1767617, encodeId=c1511e67617b2, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Fri May 10 18:28:00 CST 2019, time=2019-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=374290, encodeId=13633e4290d0, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Wed Oct 23 11:32:26 CST 2019, time=2019-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081537, encodeId=9a89208153e2d, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Mon Jan 13 22:28:00 CST 2020, time=2020-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070090, encodeId=105d20e009069, content=<a href='/topic/show?id=9ced1018209a' target=_blank style='color:#2F92EE;'>#骨组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101820, encryptionId=9ced1018209a, topicName=骨组织工程)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Mon Feb 17 06:28:00 CST 2020, time=2020-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076356, encodeId=408520e6356a5, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Fri Feb 07 21:28:00 CST 2020, time=2020-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918567, encodeId=418c191856e72, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Jan 23 12:28:00 CST 2020, time=2020-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368928, encodeId=bd7536892885, content=加油(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Wed Jul 03 20:06:09 CST 2019, time=2019-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368072, encodeId=d3743680e2a1, content=加油(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Thu Jun 20 19:54:04 CST 2019, time=2019-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366394, encodeId=19cb366394d6, content=学习了!(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Sat May 18 12:23:35 CST 2019, time=2019-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365267, encodeId=00d836526eab, content=加油(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Thu Apr 25 23:54:05 CST 2019, time=2019-04-25, status=1, ipAttribution=)]
    2020-01-23 sunylz
  7. [GetPortalCommentsPageByObjectIdResponse(id=1767617, encodeId=c1511e67617b2, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Fri May 10 18:28:00 CST 2019, time=2019-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=374290, encodeId=13633e4290d0, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Wed Oct 23 11:32:26 CST 2019, time=2019-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081537, encodeId=9a89208153e2d, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Mon Jan 13 22:28:00 CST 2020, time=2020-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070090, encodeId=105d20e009069, content=<a href='/topic/show?id=9ced1018209a' target=_blank style='color:#2F92EE;'>#骨组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101820, encryptionId=9ced1018209a, topicName=骨组织工程)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Mon Feb 17 06:28:00 CST 2020, time=2020-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076356, encodeId=408520e6356a5, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Fri Feb 07 21:28:00 CST 2020, time=2020-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918567, encodeId=418c191856e72, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Jan 23 12:28:00 CST 2020, time=2020-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368928, encodeId=bd7536892885, content=加油(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Wed Jul 03 20:06:09 CST 2019, time=2019-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368072, encodeId=d3743680e2a1, content=加油(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Thu Jun 20 19:54:04 CST 2019, time=2019-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366394, encodeId=19cb366394d6, content=学习了!(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Sat May 18 12:23:35 CST 2019, time=2019-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365267, encodeId=00d836526eab, content=加油(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Thu Apr 25 23:54:05 CST 2019, time=2019-04-25, status=1, ipAttribution=)]
    2019-07-03 1254a331m32暂无昵称

    加油(???_??)?

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1767617, encodeId=c1511e67617b2, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Fri May 10 18:28:00 CST 2019, time=2019-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=374290, encodeId=13633e4290d0, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Wed Oct 23 11:32:26 CST 2019, time=2019-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081537, encodeId=9a89208153e2d, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Mon Jan 13 22:28:00 CST 2020, time=2020-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070090, encodeId=105d20e009069, content=<a href='/topic/show?id=9ced1018209a' target=_blank style='color:#2F92EE;'>#骨组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101820, encryptionId=9ced1018209a, topicName=骨组织工程)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Mon Feb 17 06:28:00 CST 2020, time=2020-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076356, encodeId=408520e6356a5, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Fri Feb 07 21:28:00 CST 2020, time=2020-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918567, encodeId=418c191856e72, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Jan 23 12:28:00 CST 2020, time=2020-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368928, encodeId=bd7536892885, content=加油(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Wed Jul 03 20:06:09 CST 2019, time=2019-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368072, encodeId=d3743680e2a1, content=加油(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Thu Jun 20 19:54:04 CST 2019, time=2019-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366394, encodeId=19cb366394d6, content=学习了!(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Sat May 18 12:23:35 CST 2019, time=2019-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365267, encodeId=00d836526eab, content=加油(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Thu Apr 25 23:54:05 CST 2019, time=2019-04-25, status=1, ipAttribution=)]
    2019-06-20 1254a331m32暂无昵称

    加油(???_??)?

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1767617, encodeId=c1511e67617b2, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Fri May 10 18:28:00 CST 2019, time=2019-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=374290, encodeId=13633e4290d0, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Wed Oct 23 11:32:26 CST 2019, time=2019-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081537, encodeId=9a89208153e2d, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Mon Jan 13 22:28:00 CST 2020, time=2020-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070090, encodeId=105d20e009069, content=<a href='/topic/show?id=9ced1018209a' target=_blank style='color:#2F92EE;'>#骨组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101820, encryptionId=9ced1018209a, topicName=骨组织工程)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Mon Feb 17 06:28:00 CST 2020, time=2020-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076356, encodeId=408520e6356a5, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Fri Feb 07 21:28:00 CST 2020, time=2020-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918567, encodeId=418c191856e72, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Jan 23 12:28:00 CST 2020, time=2020-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368928, encodeId=bd7536892885, content=加油(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Wed Jul 03 20:06:09 CST 2019, time=2019-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368072, encodeId=d3743680e2a1, content=加油(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Thu Jun 20 19:54:04 CST 2019, time=2019-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366394, encodeId=19cb366394d6, content=学习了!(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Sat May 18 12:23:35 CST 2019, time=2019-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365267, encodeId=00d836526eab, content=加油(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Thu Apr 25 23:54:05 CST 2019, time=2019-04-25, status=1, ipAttribution=)]
    2019-05-18 1254a331m32暂无昵称

    学习了!(???_??)?

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1767617, encodeId=c1511e67617b2, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Fri May 10 18:28:00 CST 2019, time=2019-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=374290, encodeId=13633e4290d0, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Wed Oct 23 11:32:26 CST 2019, time=2019-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081537, encodeId=9a89208153e2d, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Mon Jan 13 22:28:00 CST 2020, time=2020-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070090, encodeId=105d20e009069, content=<a href='/topic/show?id=9ced1018209a' target=_blank style='color:#2F92EE;'>#骨组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101820, encryptionId=9ced1018209a, topicName=骨组织工程)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Mon Feb 17 06:28:00 CST 2020, time=2020-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076356, encodeId=408520e6356a5, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Fri Feb 07 21:28:00 CST 2020, time=2020-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918567, encodeId=418c191856e72, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Jan 23 12:28:00 CST 2020, time=2020-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368928, encodeId=bd7536892885, content=加油(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Wed Jul 03 20:06:09 CST 2019, time=2019-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368072, encodeId=d3743680e2a1, content=加油(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Thu Jun 20 19:54:04 CST 2019, time=2019-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366394, encodeId=19cb366394d6, content=学习了!(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Sat May 18 12:23:35 CST 2019, time=2019-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365267, encodeId=00d836526eab, content=加油(???_??)?, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43502553928, createdName=1254a331m32暂无昵称, createdTime=Thu Apr 25 23:54:05 CST 2019, time=2019-04-25, status=1, ipAttribution=)]
    2019-04-25 1254a331m32暂无昵称

    加油(???_??)?

    0