Diabetes Care:无症状糖尿病患者无法识别心肌梗死的患病率和预后

2019-04-23 xing.T 网络

由此可见,未被识别的MI在没有心脏病史的无症状糖尿病患者中普遍存在,并且导致死亡和临床MI的风险显著增加。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在通过延迟增强MRI(DE-MRI)确定无症状糖尿病患者未被识别的心肌梗死(MI)的患病率和预后意义。 

该研究为在无症状的无已知心脏病患者(n=120)中进行的前瞻性、双中心研究。两个预先指定的队列进行了MRI研究:1)1型糖尿病和慢性肾功能不全的高风险组(n=50)和2)2型糖尿病的平均风险组(n=70)。该研究的主要终点是全因死亡率和临床MI的综合事件。 

总体而言,通过DE-MRI和心电图检查发现无法识别MI的患病率分别为19%(高风险组28%和平均风险组13%)和5%。在长达5年的随访期间,总共进行了460人次每年的随访,(无)未被识别的心肌梗死的糖尿病患者死亡/MI发生率显著较高(44% vs. 7 %,高风险组为43% vs. 6%,平均风险组为44% vs. 8%;所有P<0.01)。调整Framingham风险评分、左心室射血分数和糖尿病类型后,DE-MRI确定的未被识别的MI使死亡/MI风险增加8倍(95%CI为3.0-21.1,P<0.0001)。向临床指标添加未被识别的MI显著改善了模型对不良事件的辨别能力(综合判别改善=0.156,P=0.001)。

由此可见,未被识别的MI在没有心脏病史的无症状糖尿病患者中普遍存在,并且导致死亡和临床MI的风险显著增加。 

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    2019-04-23 misszhang

    谢谢MedSci提供最新的资讯

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