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Oncotarget：膀胱癌基质纤维母细胞中Kindlin-2表达增加的影响

2017-05-01 AlexYang MedSci原创

膀胱癌基质Kindlin-2
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Kindlin-2是一种粘着斑蛋白并且在膀胱癌基质纤维母细胞中高度表达。最近，研究人员调查了Kindlin-2在膀胱癌基质纤维母细胞中的预后意义并评估了Kindlin-2对恶性肿瘤细胞的行为的影响。研究人员发现，203个石蜡包埋膀胱癌组织免疫组化染色结果表明Kindlin-2表达和晚期阶段、高级阶段和膀胱癌复发相关。Kaplan-Meier 生存分析表明，那些表现为高表达Kindlin-2的病人的

Kindlin-2是一种粘着斑蛋白并且在膀胱癌基质纤维母细胞中高度表达。最近，研究人员调查了Kindlin-2在膀胱癌基质纤维母细胞中的预后意义并评估了Kindlin-2对恶性肿瘤细胞的行为的影响。

研究人员发现，203个石蜡包埋膀胱癌组织免疫组化染色结果表明Kindlin-2表达和晚期阶段、高级阶段和膀胱癌复发相关。Kaplan-Meier 生存分析表明，那些表现为高表达Kindlin-2的病人的生存期比那些Kindlin-2低表达的病人的生存期更短（p<0.01）。多变量分析阐释了高Kindlin-2表达会导致膀胱癌较差的预后。另外，研究人员利用从人类膀胱癌组织中分离的癌症相关的纤维母细胞（CAFs），观察到了Kindlin-2的敲除降低的CAFs的激活，并导致了α-平滑肌动蛋白丝（α-SMA）和细胞外基质纤维连接蛋白表达的降低。Kindlin-2抑制同样也能减少CAF诱导的膀胱癌细胞转移和侵入。更多的是，研究人员还发现了Kindlin-2可以激活CAFs并且通过刺激TGF-β诱导的上皮-间质转变来促进膀胱癌细胞的侵入。最后，研究人员指出，这些结果支持了Kindlin-2和相关的激活的CAFs可以作为膀胱癌治疗疗法中的靶点。

原始出处：

Wu J， Yu C， Cai L et al. Effects of increased Kindlin-2 expression in bladder cancer stromal fibroblasts. Oncotarget. 10 April 2017. doi： 10.18632/oncotarget.17021.

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    2017-11-26 闆锋旦

    #target#

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    2018-01-13 12498e0fm90暂无昵称

    #纤维母细胞#

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    2017-07-04 ms7899726347904398

    #基质#

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    2017-05-08 虈亣靌

    好好学习，涨知识

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    2017-05-03 xiaogang319

    #IND#

    0

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膀胱癌是世界上最常见的泌尿系统癌症之一。不断出现的研究表明长非编码RNAs（lncRNAs）可能在癌症生物学中扮演着非常关键的作用。、最近，有研究人员在研究中发现了一个新的lncRNA，即锌指E-box结合同源异型盒（ZEB1）反义RNA（ZEB1-AS1）。研究发现，和相对的非癌组织比较，ZEB1-AS在膀胱癌组织中的表达提高了。更多的是，ZEB1-AS1的表达与膀胱癌中更高的组织学分级和TNM

Oncotarget：Jarid2在膀胱癌的肿瘤起始细胞的维护中是必需的

膀胱癌在中国是最常见的泌尿系统恶性肿瘤，并且在过去的几十年中的发生率和致死率都在增加。最近的研究表明，膀胱癌肿瘤的维持是通过一小部分稀有的细胞来实现的，并且这部分细胞具有干细胞特性。将这些肿瘤起始细胞（TICs）群作为目标可以克服耐药性膀胱癌。然而，在膀胱癌中，调控TICs的分子和遗传机制仍旧还没有被阐释。Jarid2与调控癌细胞上皮-间质转换和干细胞特性维持的信号通路有关。最近，有研究人员就Ja