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ACS Appl Mater Interfaces：新型的生物活性玻璃纤维可较好的促进骨再生

2017-11-27 MedSci MedSci原创

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电纺生物活性玻璃纤维由于其骨细胞外基质的建筑仿生学及其成分能够为骨再生和重构提供可溶性生物活性线索，而使得其在骨组织工程支架中具有很大的应用潜力。在生物活性玻璃中掺杂微量元素可进一步促进骨再生期间的成骨和血管生成。生物活性玻璃中锶对钙的阳离子取代可正向增强成骨细胞表型，同时抑制破骨细胞活性。此外，铜的添加可在组织新生过程中自发改善组织的血管化。本研究旨在制造并表征掺杂锶和铜的电纺生物活性玻璃纤维，

电纺生物活性玻璃纤维由于其骨细胞外基质的建筑仿生学及其成分能够为骨再生和重构提供可溶性生物活性线索，而使得其在骨组织工程支架中具有很大的应用潜力。在生物活性玻璃中掺杂微量元素可进一步促进骨再生期间的成骨和血管生成。生物活性玻璃中锶对钙的阳离子取代可正向增强成骨细胞表型，同时抑制破骨细胞活性。此外，铜的添加可在组织新生过程中自发改善组织的血管化。

本研究旨在制造并表征掺杂锶和铜的电纺生物活性玻璃纤维，并评估其体外骨修复/再生的潜力。本研究所制备的电纺生物活性玻璃纤维，掺杂不同比例的锶和铜。掺杂纤维释放的锶和铜在40 h内达到有效浓度，可持续4周。这些生物活性玻璃纤维通过促进成骨细胞和内皮细胞活性并抑制破骨细胞或骨吸收细胞的形成而表现出其生物活性。另外，体外实验中，不同类型细胞在电纺生物活性玻璃纤维的提取溶液中培养，显示在达到理想目标的情况下，各掺杂比例的生物活性玻璃均不会引起明显的细胞毒性。

综上所述，该研究结果表明，这种新型的生物活性玻璃纤维可较好的促进骨再生。

原始出处：

Weng L, Boda SK, et al., Binary Doping of Strontium and Copper Enhancing Osteogenesis and Angiogenesis of BioactiveGlass Nanofibers while Suppressing Osteoclast Activity. ACS Appl Mater Interfaces. 2017 Jul 26;9(29):24484-24496. doi: 10.1021/acsami.7b06521. Epub 2017 Jul 12.

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    2018-09-03 fyxzlh

    #生物活性玻璃#

    0

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    2018-04-09 shanyongle

    #ACE#

    0

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    2018-05-31 夏天与十三菇凉

    #FAC#

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    2017-11-29 yaanren

    #ACS#

    0

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    2017-11-29 lsj630

    #骨再生#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2005167, encodeId=dfb0200516e2f, content=<a href='/topic/show?id=af6e6938483' target=_blank style='color:#2F92EE;'>#生物活性玻璃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69384, encryptionId=af6e6938483, topicName=生物活性玻璃)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Mon Sep 03 08:37:00 CST 2018, time=2018-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655811, encodeId=9a051655811d7, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Mon Apr 09 16:37:00 CST 2018, time=2018-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956660, encodeId=6300195666002, content=<a href='/topic/show?id=7647e210ac' target=_blank style='color:#2F92EE;'>#FAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7210, encryptionId=7647e210ac, topicName=FAC)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Thu May 31 03:37:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279210, encodeId=e08312e9210cc, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Wed Nov 29 04:37:00 CST 2017, time=2017-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472092, encodeId=7af314e20927b, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Wed Nov 29 04:37:00 CST 2017, time=2017-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264816, encodeId=1b14264816c5, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Mon Nov 27 18:58:42 CST 2017, time=2017-11-27, status=1, ipAttribution=)]
    2017-11-27 131****1460

    学习了受益匪浅

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