Int J Cardiol:入院前CHA2DS2-VASc评分与急性心脑血管事件患者预后有何关系?

2017-06-20 xing.T MedSci原创

由此可见,急性脑血管事件的患者入院时较高的CHA2DS2-VASc评分与较高的死亡率和出院时严重残疾相关。

CHA2DS2-VASc评分已被推荐用于房颤患者发生血栓栓塞的风险评估。但是入院前CHA2DS2-VASc评分和脑卒中和TIA患者结局之间相关性的数据较稀缺。近日,心血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章,研究人员旨在评估入院前CHA2DS2-VASc评分对急性脑血管事件患者早期危险分层的预测价值。

该研究纳入了8309例急性脑卒中和TIA的患者(男性占53%,平均年龄为70±13.3岁)。该研究主要的两个终点为住院死亡率和出院时严重残疾。研究人员根据参与者入院前的CHA2DS2-VASc评分将研究人群分为4组(0-1, 2-3, 4-5 >5)。

在多变量分析中,对于 CHA2DS2-VASc评分>1的患者全因死亡率的比值比(CHA2DS2-VASc评分2-3, 4-5和>5患者的比值比分别为2.1,95%可信区间为1.2-3.6;1.8,95%可信区间为1.1-3.2;1.8,95%可信区间为1.1-3.3,P<0.001)。出院时重度残疾(mRS为4-5)的比值比显著增加与CHA2DS2-VASc评分直接相关(相比于CHA2DS2-VASc评分0-1的患者,CHA2DS2-VASc评分2-3, 4-5和>5患者的比值比分别为1.55 95%可信区间为1.14-2.12;2.42,95%可信区间为1.8-3.3;3,95%可信区间为2.19-4.27)。CHA2DS2-VASc评分每增加1分与严重残疾的风险增加21%相关。

由此可见,急性脑血管事件的患者入院时较高的CHA2DS2-VASc评分与较高的死亡率和出院时严重残疾相关。

原始出处:

Guy Topaz,et al. Pre-admission CHA2DS2-VASc score and outcome of patients with acute cerebrovascular events. International Journal of Cardiology. https://doi.org/10.1016/j.ijcard.2017.06.057

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    2017-12-29 huperzia
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    2017-09-16 quxin068
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    2017-06-21 海棠胜雪

    学习了

    0