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非常规抗体可保护血管抵御败血症

2016-04-21 佚名 生物360

非常规抗体败血症
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抗体ABTAA可在败血症时提供对血管的保护。活体显微镜的代表性图片显示了给予假性治疗、Fc、ABA或ABTAA（顺序为由左至右）的小鼠中内皮表层的厚度（黄色实心条）。 一项新的研究显示，一种防护血管免受败血症破坏的抗体能保护小鼠不死于败血症。与现有的以病原体或身体免疫反应作为标靶的不成功的败血症治疗相反，这种治疗方法是以病人的血管反应作为治疗标靶的。更重要的是，与常规的治疗抗体不同，这里所用

抗体ABTAA可在败血症时提供对血管的保护。活体显微镜的代表性图片显示了给予假性治疗、Fc、ABA或ABTAA（顺序为由左至右）的小鼠中内皮表层的厚度（黄色实心条）。

一项新的研究显示，一种防护血管免受败血症破坏的抗体能保护小鼠不死于败血症。与现有的以病原体或身体免疫反应作为标靶的不成功的败血症治疗相反，这种治疗方法是以病人的血管反应作为治疗标靶的。更重要的是，与常规的治疗抗体不同，这里所用的抗体是通过将正常情况下一种有害的蛋白转变成一种保护性蛋白而发挥作用的。

对败血症而言目前没有特定的治疗；全世界每年有1900万人罹患败血症，它是住院病人的一个主要的死亡原因。败血症涉及一种由势不可挡的感染免疫反应所驱动的全身性炎症。尤其是，血管炎症会引起血管破裂及液体渗出，这可能会导致器官衰竭及败血性休克。

TIE2是一种在内衬于血管的内皮细胞上发现的受体，它已经成为败血症的一种重要治疗标靶。该受体能支持抵御血管炎症和渗漏的内皮屏障。然而现有的能刺激TIE2或抑制ANG2（一种可阻断该受体的分泌蛋白）的化合物被证明仅仅部分有效，且在临床中不实用。Sangyeul Han和同事研发了一种能与ANG2结合的不寻常抗体，它们会形成一种激活而不是抑制ANG2和TIE2的复合物。在多种小鼠的败血症模型中，该抗体能比常规的阻断ANG2抗体更好地延长小鼠的存活时间。

将研究人员所研发的抗体与抗菌素结合能进一步地提高细菌感染所致败血症的存活率。实验显示，该抗体能稳定血管，加强屏障功能并抑制全身性炎症。这些发现将这一抗体晋升为一种败血症及其它可能涉及血管渗漏疾病（如埃博拉、疟疾及炭疽等）的潜在治疗。

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    2016-04-26 jjzouyan

    真的假的？

    0

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    2016-04-21 hekzn

    学习了长知识

    0

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    2016-04-21 李继凯

    文章高大上

    0

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    2016-04-21 李继凯

    值得关注

    0

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    2016-04-21 明崖

    自身免疫抗体也是身体自稳的表现

    0