ACS Nano:薄荷油和肉桂可帮助治疗慢性伤口

2015-07-13 佚名 生物谷

近日,研究显示被称为生物膜的传染性细菌菌落对慢性伤口和医疗器械会产生严重的卫生问题,并且很难治疗。但是现在科学家们研究了一种包裹薄荷糖和肉桂的抗菌复合物小胶囊,该胶囊既能杀死生物膜也能积极促进伤口愈合。研究人员表示,在ACS Nano杂志上报道的新材料可以进行局部抗菌治疗和消毒。许多细菌通过某种方法聚集成粘性斑块,这导致传统抗生素很难清除这些黏性斑块。医生有时会建议切除受感染的组织。然而,这种方法

近日,研究显示被称为生物膜的传染性细菌菌落对慢性伤口和医疗器械会产生严重的卫生问题,并且很难治疗。但是现在科学家们研究了一种包裹薄荷糖和肉桂的抗菌复合物小胶囊,该胶囊既能杀死生物膜也能积极促进伤口愈合。研究人员表示,在ACS Nano杂志上报道的新材料可以进行局部抗菌治疗和消毒。

许多细菌通过某种方法聚集成粘性斑块,这导致传统抗生素很难清除这些黏性斑块。医生有时会建议切除受感染的组织。然而,这种方法比较昂贵,并且因为它的入侵性,许多病人决定完全退出治疗。近期精油和其他天然化合物的出现成为清除病原菌的可替代性物质,但是研究人员很难将它们的抗菌作用转化成治疗方法。Vincent M. Rotello 和他的同事们想要应对这一挑战。

研究人员将薄荷油和肉桂醛包裹到二氧化硅纳米粒子胶囊外皮中,肉桂的作用主要是风味和香气。这种微型胶囊对四种不同类型的细菌治疗是有效的,甚至对抗生素耐药菌株的治疗也是有效的。它还能促进成纤维细胞的生长,该细胞对伤口愈合至关重要。

原始出处:

Bradley Duncan †, Xiaoning Li †, Ryan F. Landis †, Sung Tae Kim †, Akash Gupta †, Li-Sheng Wang †, Rajesh Ramanathan †‡, Rui Tang †, Jeffrey A. Boerth †, and Vincent M. Rotello *†.Nanoparticle-Stabilized Capsules for the Treatment of Bacterial Biofilms.ACS NANO.June 17, 2015.DOI: 10.1021/acsnano.5b01696

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1743767, encodeId=72f81e43767be, content=<a href='/topic/show?id=6d40534e088' target=_blank style='color:#2F92EE;'>#慢性伤口#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53470, encryptionId=6d40534e088, topicName=慢性伤口)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7f2735217910, createdName=drwjr, createdTime=Thu Sep 10 16:27:00 CST 2015, time=2015-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279094, encodeId=ca9612e909479, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Wed Jul 15 02:27:00 CST 2015, time=2015-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32716, encodeId=535132e1638, content=关键问题是中药成分的标准认定, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Tue Jul 14 11:08:00 CST 2015, time=2015-07-14, status=1, ipAttribution=)]
    2015-07-15 yaanren
  3. [GetPortalCommentsPageByObjectIdResponse(id=1743767, encodeId=72f81e43767be, content=<a href='/topic/show?id=6d40534e088' target=_blank style='color:#2F92EE;'>#慢性伤口#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53470, encryptionId=6d40534e088, topicName=慢性伤口)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7f2735217910, createdName=drwjr, createdTime=Thu Sep 10 16:27:00 CST 2015, time=2015-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279094, encodeId=ca9612e909479, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Wed Jul 15 02:27:00 CST 2015, time=2015-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32716, encodeId=535132e1638, content=关键问题是中药成分的标准认定, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Tue Jul 14 11:08:00 CST 2015, time=2015-07-14, status=1, ipAttribution=)]
    2015-07-14 lovejing

    关键问题是中药成分的标准认定

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