CLIN CHEM LAB MED:粪便免疫化学检测在缺铁性贫血内镜调查决策过程中的应用

2020-03-17 MedSci原创 MedSci原创

胃肠道失血是成年男性和绝经后女性缺铁性贫血最常见的原因之一。胃十二指肠内窥镜检查(GDE)和结肠镜检查是常用的检测方法,尽管尚不确定上消化道和下消化道是否同时存在病变。

胃肠道失血是成年男性和绝经后女性缺铁性贫血最常见的原因之一。胃十二指肠内窥镜检查(GDE)和结肠镜检查是常用的检测方法,尽管尚不确定上消化道和下消化道是否同时存在病变。粪便免疫化学测试(FIT)仅可测量源自结肠或直肠的粪便血红蛋白(f-Hb)的浓度。我们旨在评估FIT是否能够选择最佳的内窥镜检查程序来检测IDA的原因。

本研究对120名男性和绝经后女性进行的IDA诊断性研究,采用FIT、GDE和结肠镜检查进行评估。内镜发现明显的上段病变(SUL)或明显的肠部病变(SBL)被认为是引起IDA的原因。

研究结果显示,35.0%为SUL,20.0%为SBL,包括13.3%消化道癌。在多变量分析中,血红蛋白(b-Hb)<9 g / dL(OR:2.60; 95%CI 1.13–6.00; p = 0.025)和非甾体类抗炎药NSAIDs(2.56; 1.13– 5.88; p = 0.024)与SUL相关。 年龄(0.93; 0.88–0.99; p = 0.042)和f-Hb≥15μgHb / g粪便(38.53; 8.60–172.50; p <0.001)与SBL相关。 只有在f-Hb≥15μgHb / g粪便时才进行结肠镜检查的“ FIT加胃镜检查”策略可以检测92.4%的病变,并在癌症检测中100%准确,同时避免71.6%的癌症。

研究表明,FIT是一种选择最佳内窥镜检查研究以评估IDA的准确方法。 基于FIT的策略比当前基于双向内窥镜的策略更具成本效益,并且可以改善内窥镜资源分配。

原始出处:

Lorena Rodriguez-Alonso,Francisco Rodriguez-Moranta,The use of faecal immunochemical testing in the decision-making process for the endoscopic investigation of iron deficiency anaemia

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    2020-03-19 Homburg
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