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Diabetes Care：妊娠前SHBG低浓度与妊娠糖尿病风险升高相关

2014-02-27 高晓方 译 医学论坛网

妊娠前SHBG低浓度妊娠糖尿病风险
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美国一项研究表明，妊娠前性激素结合球蛋白(SHBG)浓度较低与妊娠糖尿病风险升高相关，并有望用于确认妊娠糖尿病高危女性。论文2月21日在线发表于《糖尿病护理》(Diabetes Care)。 既往研究表明，绝经前女性SHBG浓度较低与糖尿病风险升高相关。此项巢式病例对照研究以基线时无糖尿病并且后续出现妊娠的女性为受试者。以发生妊娠糖尿病的256例女性为病例患者。为病例患者各选择2例检验时间、年龄

美国一项研究表明，妊娠前性激素结合球蛋白(SHBG)浓度较低与妊娠糖尿病风险升高相关，并有望用于确认妊娠糖尿病高危女性。论文2月21日在线发表于《糖尿病护理》(Diabetes Care)。

既往研究表明，绝经前女性SHBG浓度较低与糖尿病风险升高相关。此项巢式病例对照研究以基线时无糖尿病并且后续出现妊娠的女性为受试者。以发生妊娠糖尿病的256例女性为病例患者。为病例患者各选择2例检验时间、年龄、妊娠年龄和妊娠干预次数相匹配的对照者。评估妊娠前SHBG与妊娠糖尿病风险的相关性。

结果显示，对糖尿病家族史、妊娠前体质指数(BMI)、种族、饮酒、妊娠前体重变化和胰岛素抵抗进行校正之后，与SHBG浓度最高四分位相比，妊娠糖尿病机率随四分位数降低而升高。与SHBG水平≥均值的正常体重女性相比，SHBG水平低于均值(<64.5 nmol/L)以及BMI ≥25.0 kg/m2与妊娠糖尿病机率升高5倍具有相关性。

原始出处：

Hedderson MM1, Xu F, Darbinian JA, Quesenberry CP, Sridhar S, Kim C, Gunderson EP, Ferrara A.Prepregnancy SHBG Concentrations and Risk for Subsequently Developing Gestational Diabetes Mellitus.Diabetes Care. 2014 Feb 21. 


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    2014-04-25 1249898am15暂无昵称

    #妊娠前#

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    2014-09-14 智智灵药

    #BET#

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    2014-05-26 ms9608593228839890

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    2014-03-04 木头人513

    #Diabetes#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1946740, encodeId=cc341946e40c4, content=<a href='/topic/show?id=8a0844838ca' target=_blank style='color:#2F92EE;'>#妊娠前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44838, encryptionId=8a0844838ca, topicName=妊娠前)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38232500109, createdName=1249898am15暂无昵称, createdTime=Fri Apr 25 11:59:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759413, encodeId=c71a1e5941340, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sun Sep 14 02:59:00 CST 2014, time=2014-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636825, encodeId=de34163682540, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Mon May 26 08:59:00 CST 2014, time=2014-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901188, encodeId=3d7d1901188db, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Tue Mar 04 23:59:00 CST 2014, time=2014-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=8362, encodeId=b1f58362e8, content=希望国内尽快引进相关试剂盒和相关方案, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f4d91418, createdName=zyc790710, createdTime=Mon Mar 17 18:03:00 CST 2014, time=2014-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544382, encodeId=3b681544382fa, content=<a href='/topic/show?id=ac3d6549e75' target=_blank style='color:#2F92EE;'>#浓度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65497, encryptionId=ac3d6549e75, topicName=浓度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16b213663040, createdName=12498974m55暂无昵称, createdTime=Sat Mar 01 02:59:00 CST 2014, time=2014-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602820, encodeId=6a90160282057, content=<a href='/topic/show?id=dea516245a3' target=_blank style='color:#2F92EE;'>#SHBG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16245, encryptionId=dea516245a3, topicName=SHBG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a2b18942585, createdName=zhty5343, createdTime=Sat Mar 01 02:59:00 CST 2014, time=2014-03-01, status=1, ipAttribution=)]
    2014-03-17 zyc790710

    希望国内尽快引进相关试剂盒和相关方案

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1946740, encodeId=cc341946e40c4, content=<a href='/topic/show?id=8a0844838ca' target=_blank style='color:#2F92EE;'>#妊娠前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44838, encryptionId=8a0844838ca, topicName=妊娠前)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38232500109, createdName=1249898am15暂无昵称, createdTime=Fri Apr 25 11:59:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759413, encodeId=c71a1e5941340, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sun Sep 14 02:59:00 CST 2014, time=2014-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636825, encodeId=de34163682540, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Mon May 26 08:59:00 CST 2014, time=2014-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901188, encodeId=3d7d1901188db, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Tue Mar 04 23:59:00 CST 2014, time=2014-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=8362, encodeId=b1f58362e8, content=希望国内尽快引进相关试剂盒和相关方案, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f4d91418, createdName=zyc790710, createdTime=Mon Mar 17 18:03:00 CST 2014, time=2014-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544382, encodeId=3b681544382fa, content=<a href='/topic/show?id=ac3d6549e75' target=_blank style='color:#2F92EE;'>#浓度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65497, encryptionId=ac3d6549e75, topicName=浓度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16b213663040, createdName=12498974m55暂无昵称, createdTime=Sat Mar 01 02:59:00 CST 2014, time=2014-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602820, encodeId=6a90160282057, content=<a href='/topic/show?id=dea516245a3' target=_blank style='color:#2F92EE;'>#SHBG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16245, encryptionId=dea516245a3, topicName=SHBG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a2b18942585, createdName=zhty5343, createdTime=Sat Mar 01 02:59:00 CST 2014, time=2014-03-01, status=1, ipAttribution=)]
    2014-03-01 12498974m55暂无昵称

    #浓度#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1946740, encodeId=cc341946e40c4, content=<a href='/topic/show?id=8a0844838ca' target=_blank style='color:#2F92EE;'>#妊娠前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44838, encryptionId=8a0844838ca, topicName=妊娠前)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38232500109, createdName=1249898am15暂无昵称, createdTime=Fri Apr 25 11:59:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759413, encodeId=c71a1e5941340, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sun Sep 14 02:59:00 CST 2014, time=2014-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636825, encodeId=de34163682540, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Mon May 26 08:59:00 CST 2014, time=2014-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901188, encodeId=3d7d1901188db, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Tue Mar 04 23:59:00 CST 2014, time=2014-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=8362, encodeId=b1f58362e8, content=希望国内尽快引进相关试剂盒和相关方案, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f4d91418, createdName=zyc790710, createdTime=Mon Mar 17 18:03:00 CST 2014, time=2014-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544382, encodeId=3b681544382fa, content=<a href='/topic/show?id=ac3d6549e75' target=_blank style='color:#2F92EE;'>#浓度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65497, encryptionId=ac3d6549e75, topicName=浓度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16b213663040, createdName=12498974m55暂无昵称, createdTime=Sat Mar 01 02:59:00 CST 2014, time=2014-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602820, encodeId=6a90160282057, content=<a href='/topic/show?id=dea516245a3' target=_blank style='color:#2F92EE;'>#SHBG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16245, encryptionId=dea516245a3, topicName=SHBG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a2b18942585, createdName=zhty5343, createdTime=Sat Mar 01 02:59:00 CST 2014, time=2014-03-01, status=1, ipAttribution=)]
    2014-03-01 zhty5343

    #SHBG#

    0