J Ment Health：互联网认知行为治疗的3.5年随访

　　近期发表于《J Ment Health》杂志上的一项研究表明，轻度至中度抑郁症患者可能会在互联网认知行为治疗（ICBT）治疗后3.5年内受益。

　　多项实验已检测互联网对重型抑郁症的认知行为治疗效果，但随访时间只有1.5年。这项研究的目的是评估ICBT治疗完成3.5年后的结果。

　　在原始试验中，共有88名重型抑郁症患者被随机分配至有指导的自助和电子邮件治疗组。三分之一最初位于候补名单上。治疗持续了8周，报告收集了长期随访的试验数据。还包括治疗后和6个月随访的数据。58％（51/88）共完成3.5年的随访。采用随机效应反复测量分段增长模型估计轨迹形状随时间推移的变化并对缺失数据进行分析。

　　结果显示，贝克抑郁量表（BDI）分数持续降低。处理条件之间没有显著差异。在随访期间很大比例的受试者（55％）已寻求并获得额外的治疗。在3.5年的随访中，大多数（56.9％）的受试者BDI分数低于10。

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A 3.5-year follow-up of Internet-delivered cognitive behavior therapy for major depression.
Background
Internet-delivered cognitive behavior therapy (ICBT) for major depression has been tested in several trials, but only with follow-ups up to 1.5 years. Aim The aim of this study was to evaluate the outcome of ICBT 3.5 years after treatment completion.
Methods
A total of 88 people with major depression were randomized to either guided self-help or e-mail therapy in the original trial. One-third was initially on a waiting-list. Treatment was provided for eight weeks and in this report long-term follow-up data were collected. Also included were data from post-treatment and six-month follow-up. A total of 58% (51/88) completed the 3.5-year follow-up. Analyses were performed using a random effects repeated measures piecewise growth model to estimate trajectory shape over time and account for missing data.
Results
Results showed continued lowered scores on the Beck Depression Inventory (BDI). No differences were found between the treatment conditions. A large proportion of participants (55%) had sought and received additional treatments in the follow-up period. A majority (56.9%) of participants had a BDI score lower than 10 at the 3.5-year follow-up.
Conclusions
People with mild to moderate major depression may benefit from ICBT 3.5-years after treatment completion.