NAT COMMU:生活在女性生殖道中的大量微生物群落

2017-10-18 MedSci MedSci原创

来自中国的大型研究团队(以及来自挪威和丹麦的研究团队)发现,女性生殖道是比人们想象的更丰富的微生物群落的宿主。在发表在《自然通讯》(Nature Communications)杂志上的论文中,报告收集了志愿妇女生殖器官的几个部位的样本,以及他们在研究中发现的内容。科学家们早就知道,阴道会容纳一个密集的微生物群落,那里生活着数以万亿计的细菌。但是,正如研究人员指出的那样,生殖系统其他部分存在的生物群


来自中国的大型研究团队(以及来自挪威和丹麦的研究团队)发现,女性生殖道是比人们想象的更丰富的微生物群落的宿主。在发表在《自然通讯》(Nature Communications)杂志上的论文中,报告收集了志愿妇女生殖器官的几个部位的样本,以及他们在研究中发现的内容。

科学家们早就知道,阴道会容纳一个密集的微生物群落,那里生活着数以万亿计的细菌。但是,正如研究人员指出的那样,生殖系统其他部分存在的生物群落知之甚少。为了了解更多,研究人员招募了110名育龄期女性志愿者,收集从阴道到输卵管的一个或多个部位的样本。有些样品是在例行的办公室访问期间获得的,有些则是在先前的腹腔镜检查过程中获得的。

研究人员对所有样本进行了16S rRNA测序,以确定哪些微生物在生殖道的哪一部分存活。分类后,研究人员整理了所有的数据,以便单个妇女间进行比较。研究小组证实了早期的发现,阴道里充满了细菌,尤其是乳酸菌。但他们也发现其他部位有不同的微生物--例如,在子宫或输卵管内壁的乳酸菌很少; 相反,有更多的假单胞菌。他们还报告说,微生物群落根据妇女在月经周期中的位置而个别改变。他们发现,具有疾病或病症的妇女,如有良性子宫肿瘤时,微生物群落是不同的。

研究小组报告说,他们还发现了证据表明,与流行观点相反的是,婴儿在子宫内发育时并不处于无菌环境中,胎盘也不是无菌的。研究人员指出,他们的工作只是对女性生殖道微生物群落进行更大努力的开端。他们建议进行更多的研究,以便更好地了解什么是正常的,什么不是,以及生殖系统疾病和治疗方法。


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    2018-07-27 liye789132251
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    2017-10-18 中医痴

    不错的.学习了.谢谢分享!

    0