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Biofabrication：在中空介孔生物玻璃支架中加入氧化铈可通过激活ERK信号通路促进骨再生

2019-02-14 不详 网络

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人造生物材料的分层多孔结构和生物活性组合物在骨缺损愈合和新骨再生中起积极作用。本研究中，研究人员通过冷冻干燥技术在CTS中掺入中空介孔Ce-BG微球，构建氧化铈纳米颗粒改性生物玻璃（Ce-BG）支架。Ce-BG支架中相互连接的大孔促进了骨细胞/组织从材料表面向内部的生长，而Ce-BG微球中的中空核和中孔壳为骨矿化提供了更多的活性位点。支架中的氧化铈纳米颗粒迅速促进人骨髓间充质干细胞（hBMSC）的

人造生物材料的分层多孔结构和生物活性组合物在骨缺损愈合和新骨再生中起积极作用。

本研究中，研究人员通过冷冻干燥技术在CTS中掺入中空介孔Ce-BG微球，构建氧化铈纳米颗粒改性生物玻璃（Ce-BG）支架。Ce-BG支架中相互连接的大孔促进了骨细胞/组织从材料表面向内部的生长，而Ce-BG微球中的中空核和中孔壳为骨矿化提供了更多的活性位点。

支架中的氧化铈纳米颗粒迅速促进人骨髓间充质干细胞（hBMSC）的增殖和成骨分化，成骨相关标志物如OCN，ALP和COL-1的表达上调。Ce-BG支架的增强的骨诱导性主要与激活的ERK通路有关，并且通过添加选择性ERK1/2抑制剂（SCH772984）而阻断。体内大鼠颅骨缺损模型显示，与BG支架相比，Ce-BG支架加速胶原沉积，成骨细胞形成和骨再生。

综上所述，该研究结果表明，分层多孔结构和氧化铈纳米颗粒之间的协同效应有助于成骨能力，中空介孔Ce-BG支架将成为骨再生的新平台。

原始出处：

Lu B, Zhu DY, et al., Incorporation of cerium oxide in hollow mesoporous bioglass scaffolds for enhanced bone regeneration by activating ERK signaling pathway. Biofabrication. 2019 Feb 12. doi: 10.1088/1758-5090/ab0676.

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    2019-08-20 sunylz

    #Bio#

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    2019-08-07 luckyshitiancai_42705692

    #介孔#

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    2019-11-21 chenlianhui

    #ERK#

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    2019-02-16 lsj630

    #骨再生#

    0

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    2019-02-16 wgx310

    #信号通路#

    0