Medicine:肥胖诱导的氧化应激与机体牙周疾病的发生有关

2016-03-27 MedSci MedSci原创

Medicine:肥胖诱导的氧化应激与机体牙周疾病的发生有关牙周病是一种慢性炎症性疾病,更常见于肥胖人群。局部和全身的氧化应激可能是牙周病和肥胖早期关联的因素。本研究旨在检测肥胖者的牙周疾病易感性的增加是否与局部和全身的氧化应激有关。因此,本研究中,研究人员对比了年轻肥胖女性与年龄匹配的较瘦女性的牙周状况及全身(血清)和局部(龈沟液)氧化应激标志物的状态。研究共纳入了20名肥胖女性和20名较瘦的女

牙周病是一种慢性炎症性疾病,更常见于肥胖人群。局部和全身的氧化应激可能是牙周病和肥胖早期关联的因素。本研究旨在检测肥胖者的牙周疾病易感性的增加是否与局部和全身的氧化应激有关。

因此,本研究中,研究人员对比了年轻肥胖女性与年龄匹配的较瘦女性的牙周状况及全身(血清)和局部(龈沟液)氧化应激标志物的状态。研究共纳入了20名肥胖女性和20名较瘦的女性。测量各临床牙周指数,包括探诊深度、临床附着水平、牙龈指数、牙龈出血指数和斑块指数以评估所有研究对象的牙周状态。此外,还评估了所有研究对象的激素和代谢状况。空腹一晚后采集所有研究对象的血液和龈沟液样本。测定血清和龈沟液的总抗氧化能力,以及总的氧化状态水平,并计算氧化应激指数。

结果显示,牙周临床分析表明肥胖组女性的牙龈指数和牙龈出血指数高于较瘦组女性,而探测深度、临床附着水平以及菌斑指数在两组之间并无差异。氧化状态分析显示,肥胖组女性的龈沟液和血清总抗氧化能力较低,而血清氧化应激指数值较高。肥胖组女性龈沟液总的氧化应激状态较高,而血清总的氧化应激状态并未明显升高。龈沟液总的氧化应激能力值与身体质量指数呈负相关,而龈沟液氧化应激指数与空腹胰岛素和低密度脂蛋白胆固醇的水平呈正相关。临床牙周指数与身体质量指数,胰岛素,血脂水平,以及氧化应激状态标志物之间具有明显的相关关系。

总而言之,我们的研究结果表明,与同龄健康的较瘦女性相比,年轻肥胖女性早期的牙周疾病(牙龈炎)及肥胖所诱导的局部/牙周的氧化应激与牙周疾病有关。

原始出处:

Dursun E, Akaln FA, Genc T, Cinar N, Erel O, Yildiz BO. Oxidative Stress and Periodontal Disease in Obesity. Medicine (Baltimore). 2016 Mar;95(12):e3136. doi: 10.1097/MD.0000000000003136.

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06:09:00 CST 2016, time=2016-03-29, status=1, ipAttribution=)]
    2016-10-12 jeanqiuqiu
  2. 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06:09:00 CST 2016, time=2016-03-29, status=1, ipAttribution=)]
    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

    0

  3. 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    2016-09-13 ylzr123

    赞一个!好文章拜读了,认真学习了。

    0

  4. 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encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9a038523631, createdName=kalseyzl, createdTime=Sun Jul 17 17:09:00 CST 2016, time=2016-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445123, encodeId=f66d1445123c6, content=<a href='/topic/show?id=61e74928629' target=_blank style='color:#2F92EE;'>#应激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49286, encryptionId=61e74928629, topicName=应激)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Tue Mar 29 06:09:00 CST 2016, time=2016-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450459, encodeId=e681145045972, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, 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href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Tue Mar 29 06:09:00 CST 2016, time=2016-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606879, encodeId=a47c16068e977, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Mar 29 06:09:00 CST 2016, time=2016-03-29, status=1, ipAttribution=)]
    2016-07-17 kalseyzl
  5. 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06:09:00 CST 2016, time=2016-03-29, status=1, ipAttribution=)]
  6. 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  7. 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