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Biosci Rep：六味地黄丸可用于治疗糖尿病肾病相关的骨质疏松症

2020-10-03 MedSci原创 MedSci原创

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六味地黄丸（LWDH）对糖尿病肾病相关骨质疏松症（DNOP）的影响尚不明确。本研究旨在评价LWDH对DNOP大鼠及高糖诱导的MC3T3-E1细胞的KDM7A和Wnt/β-catenin信号通

六味地黄丸（LWDH）对糖尿病肾病相关骨质疏松症（DNOP）的影响尚不明确。本研究旨在评价LWDH对DNOP大鼠及高糖诱导的MC3T3-E1细胞的KDM7A和Wnt/β-catenin信号通路的影响，研究结果已在线发表于Biosci Rep。

以9周龄雄性Sprague-Dawley(SD)大鼠为研究对象，用链脲佐菌素制备DNOP模型，评价LWDH的影响。分别通过CCK-8测定、Alizarin红染色和碱性磷酸酶(ALP)染色测定高糖诱导的MC3T3-E1细胞的细胞活力和分化能力。此外，通过Western blot分析测定KDM7A和Wnt1/β-catenin通路相关蛋白的表达。

 

结果显示，使用LWDH治疗DNOP大鼠可明显改善大鼠的一般状态、肾功能的退化和肾脏病理变化。LWDH可降低TNF-α、IL-6、IL-8、IL-1β、ALP和TRAP的水平，提高血清中钙、磷的含量，降低尿液中钙、磷的含量。此外，LWDH能显著改善DNOP大鼠的骨密度(BMD)、骨量(BV)和骨微结构。此外，LWDH还提高了股骨的弹性模量、极限载荷和弯曲强度。在MC3T3-E1细胞中，含血清的LWDH能显著提高细胞活力和成骨细胞分化能力。α-SMA、vimentin、KDM7A、Wnt1和β-catenin的表达明显下调，E-cadherin、H3K9-Me2、H3K27-Me2、BMP-4、BMP-7、Runx2、骨钙素和Col1a1的表达在LWDH处理后明显上调。

综上所述，该研究结果表明，LWDH对DNOP有治疗作用，部分是通过下调KDM7A和Wnt/β-catenin通路。

 

原始出处：

 

Ming Ming Liu, Rui Dong, et al., Therapeutic potential of Liuwei Dihuang pill against KDM7A and Wnt/β-catenin signaling pathway in diabetic nephropathy-related osteoporosis. Biosci Rep. 2020 Sep 30;40(9):BSR20201778. doi: 10.1042/BSR20201778.

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    2021-11-21 ms4000000161062034

    谢谢，学习了

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1072399, encodeId=967010e239973, content=谢谢，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446e5632316, createdName=ms4000000161062034, createdTime=Sun Nov 21 06:15:40 CST 2021, time=2021-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897114, encodeId=d37089e114ac, content=<a href='/topic/show?id=a92c29945eb' target=_blank style='color:#2F92EE;'>#六味地黄丸#</a>可用于治疗<a href='/topic/show?id=b081e6760b8' target=_blank style='color:#2F92EE;'>#糖尿病肾病#</a>相关的<a href='/topic/show?id=e59810186916' target=_blank style='color:#2F92EE;'>#骨质疏松症#</a>，在大剂量可能是有效的，目前<a href='/topic/show?id=5c1d22423c8' target=_blank style='color:#2F92EE;'>#中药#</a>材的质量不好，因此导致疗效不理想。另外，中成药的有效成分含量太低，难以达到有效作用，实际上临床上应用，除非大剂量使用才可能有用。 大家知道，水煎中药，是一大包，而<a href='/topic/show?id=4c45222205b' target=_blank style='color:#2F92EE;'>#中成药#</a>，才几粒，能否有效，可想而知的，主要问题是剂量不够！, beContent=null, objectType=article, channel=null, level=null, likeNumber=319, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=29945, encryptionId=a92c29945eb, topicName=六味地黄丸), TopicDto(id=76760, encryptionId=b081e6760b8, topicName=糖尿病肾病), TopicDto(id=101869, encryptionId=e59810186916, topicName=骨质疏松症), TopicDto(id=22423, encryptionId=5c1d22423c8, topicName=中药), TopicDto(id=22220, encryptionId=4c45222205b, topicName=中成药)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Nov 05 14:03:14 CST 2020, time=2020-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1919136, encodeId=474f191913602, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Apr 23 17:11:23 CST 2021, time=2021-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592644, encodeId=d27d1592644de, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Sun Oct 04 15:11:23 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889824, encodeId=6c1988982408, content=看标题还以为真有效果呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00074131254, createdName=13c30453m58暂无昵称, createdTime=Sat Oct 03 08:25:32 CST 2020, time=2020-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043350, encodeId=07b510433501f, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Oct 03 03:11:23 CST 2020, time=2020-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889782, encodeId=efd9889e825c, content=图不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f804870411, createdName=1419516246, createdTime=Sat Oct 03 00:22:50 CST 2020, time=2020-10-03, status=1, ipAttribution=)]
    2020-11-05 lovetcm

    #六味地黄丸#可用于治疗#糖尿病肾病#相关的#骨质疏松症#，在大剂量可能是有效的，目前#中药#材的质量不好，因此导致疗效不理想。另外，中成药的有效成分含量太低，难以达到有效作用，实际上临床上应用，除非大剂量使用才可能有用。 大家知道，水煎中药，是一大包，而#中成药#，才几粒，能否有效，可想而知的，主要问题是剂量不够！

    1

    展开1条回复
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    2021-04-23 sunylz

    #Bio#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1072399, encodeId=967010e239973, content=谢谢，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446e5632316, createdName=ms4000000161062034, createdTime=Sun Nov 21 06:15:40 CST 2021, time=2021-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897114, encodeId=d37089e114ac, content=<a href='/topic/show?id=a92c29945eb' target=_blank style='color:#2F92EE;'>#六味地黄丸#</a>可用于治疗<a href='/topic/show?id=b081e6760b8' target=_blank style='color:#2F92EE;'>#糖尿病肾病#</a>相关的<a href='/topic/show?id=e59810186916' target=_blank style='color:#2F92EE;'>#骨质疏松症#</a>，在大剂量可能是有效的，目前<a href='/topic/show?id=5c1d22423c8' target=_blank style='color:#2F92EE;'>#中药#</a>材的质量不好，因此导致疗效不理想。另外，中成药的有效成分含量太低，难以达到有效作用，实际上临床上应用，除非大剂量使用才可能有用。 大家知道，水煎中药，是一大包，而<a href='/topic/show?id=4c45222205b' target=_blank style='color:#2F92EE;'>#中成药#</a>，才几粒，能否有效，可想而知的，主要问题是剂量不够！, beContent=null, objectType=article, channel=null, level=null, likeNumber=319, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=29945, encryptionId=a92c29945eb, topicName=六味地黄丸), TopicDto(id=76760, encryptionId=b081e6760b8, topicName=糖尿病肾病), TopicDto(id=101869, encryptionId=e59810186916, topicName=骨质疏松症), TopicDto(id=22423, encryptionId=5c1d22423c8, topicName=中药), TopicDto(id=22220, encryptionId=4c45222205b, topicName=中成药)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Nov 05 14:03:14 CST 2020, time=2020-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1919136, encodeId=474f191913602, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Apr 23 17:11:23 CST 2021, time=2021-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592644, encodeId=d27d1592644de, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Sun Oct 04 15:11:23 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889824, encodeId=6c1988982408, content=看标题还以为真有效果呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00074131254, createdName=13c30453m58暂无昵称, createdTime=Sat Oct 03 08:25:32 CST 2020, time=2020-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043350, encodeId=07b510433501f, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Oct 03 03:11:23 CST 2020, time=2020-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889782, encodeId=efd9889e825c, content=图不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f804870411, createdName=1419516246, createdTime=Sat Oct 03 00:22:50 CST 2020, time=2020-10-03, status=1, ipAttribution=)]
    2020-10-04 Eleven17

    #骨质#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1072399, encodeId=967010e239973, content=谢谢，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446e5632316, createdName=ms4000000161062034, createdTime=Sun Nov 21 06:15:40 CST 2021, time=2021-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897114, encodeId=d37089e114ac, content=<a href='/topic/show?id=a92c29945eb' target=_blank style='color:#2F92EE;'>#六味地黄丸#</a>可用于治疗<a href='/topic/show?id=b081e6760b8' target=_blank style='color:#2F92EE;'>#糖尿病肾病#</a>相关的<a href='/topic/show?id=e59810186916' target=_blank style='color:#2F92EE;'>#骨质疏松症#</a>，在大剂量可能是有效的，目前<a href='/topic/show?id=5c1d22423c8' target=_blank style='color:#2F92EE;'>#中药#</a>材的质量不好，因此导致疗效不理想。另外，中成药的有效成分含量太低，难以达到有效作用，实际上临床上应用，除非大剂量使用才可能有用。 大家知道，水煎中药，是一大包，而<a href='/topic/show?id=4c45222205b' target=_blank style='color:#2F92EE;'>#中成药#</a>，才几粒，能否有效，可想而知的，主要问题是剂量不够！, beContent=null, objectType=article, channel=null, level=null, likeNumber=319, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=29945, encryptionId=a92c29945eb, topicName=六味地黄丸), TopicDto(id=76760, encryptionId=b081e6760b8, topicName=糖尿病肾病), TopicDto(id=101869, encryptionId=e59810186916, topicName=骨质疏松症), TopicDto(id=22423, encryptionId=5c1d22423c8, topicName=中药), TopicDto(id=22220, encryptionId=4c45222205b, topicName=中成药)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Nov 05 14:03:14 CST 2020, time=2020-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1919136, encodeId=474f191913602, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Apr 23 17:11:23 CST 2021, time=2021-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592644, encodeId=d27d1592644de, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Sun Oct 04 15:11:23 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889824, encodeId=6c1988982408, content=看标题还以为真有效果呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00074131254, createdName=13c30453m58暂无昵称, createdTime=Sat Oct 03 08:25:32 CST 2020, time=2020-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043350, encodeId=07b510433501f, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Oct 03 03:11:23 CST 2020, time=2020-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889782, encodeId=efd9889e825c, content=图不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f804870411, createdName=1419516246, createdTime=Sat Oct 03 00:22:50 CST 2020, time=2020-10-03, status=1, ipAttribution=)]
    2020-10-03 13c30453m58暂无昵称

    看标题还以为真有效果呢

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1072399, encodeId=967010e239973, content=谢谢，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446e5632316, createdName=ms4000000161062034, createdTime=Sun Nov 21 06:15:40 CST 2021, time=2021-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897114, encodeId=d37089e114ac, content=<a href='/topic/show?id=a92c29945eb' target=_blank style='color:#2F92EE;'>#六味地黄丸#</a>可用于治疗<a href='/topic/show?id=b081e6760b8' target=_blank style='color:#2F92EE;'>#糖尿病肾病#</a>相关的<a href='/topic/show?id=e59810186916' target=_blank style='color:#2F92EE;'>#骨质疏松症#</a>，在大剂量可能是有效的，目前<a href='/topic/show?id=5c1d22423c8' target=_blank style='color:#2F92EE;'>#中药#</a>材的质量不好，因此导致疗效不理想。另外，中成药的有效成分含量太低，难以达到有效作用，实际上临床上应用，除非大剂量使用才可能有用。 大家知道，水煎中药，是一大包，而<a href='/topic/show?id=4c45222205b' target=_blank style='color:#2F92EE;'>#中成药#</a>，才几粒，能否有效，可想而知的，主要问题是剂量不够！, beContent=null, objectType=article, channel=null, level=null, likeNumber=319, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=29945, encryptionId=a92c29945eb, topicName=六味地黄丸), TopicDto(id=76760, encryptionId=b081e6760b8, topicName=糖尿病肾病), TopicDto(id=101869, encryptionId=e59810186916, topicName=骨质疏松症), TopicDto(id=22423, encryptionId=5c1d22423c8, topicName=中药), TopicDto(id=22220, encryptionId=4c45222205b, topicName=中成药)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Nov 05 14:03:14 CST 2020, time=2020-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1919136, encodeId=474f191913602, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Apr 23 17:11:23 CST 2021, time=2021-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592644, encodeId=d27d1592644de, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Sun Oct 04 15:11:23 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889824, encodeId=6c1988982408, content=看标题还以为真有效果呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00074131254, createdName=13c30453m58暂无昵称, createdTime=Sat Oct 03 08:25:32 CST 2020, time=2020-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043350, encodeId=07b510433501f, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Oct 03 03:11:23 CST 2020, time=2020-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889782, encodeId=efd9889e825c, content=图不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f804870411, createdName=1419516246, createdTime=Sat Oct 03 00:22:50 CST 2020, time=2020-10-03, status=1, ipAttribution=)]
    2020-10-03 misszhang

    谢谢MedSci提供最新的资讯

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1072399, encodeId=967010e239973, content=谢谢，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446e5632316, createdName=ms4000000161062034, createdTime=Sun Nov 21 06:15:40 CST 2021, time=2021-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897114, encodeId=d37089e114ac, content=<a href='/topic/show?id=a92c29945eb' target=_blank style='color:#2F92EE;'>#六味地黄丸#</a>可用于治疗<a href='/topic/show?id=b081e6760b8' target=_blank style='color:#2F92EE;'>#糖尿病肾病#</a>相关的<a href='/topic/show?id=e59810186916' target=_blank style='color:#2F92EE;'>#骨质疏松症#</a>，在大剂量可能是有效的，目前<a href='/topic/show?id=5c1d22423c8' target=_blank style='color:#2F92EE;'>#中药#</a>材的质量不好，因此导致疗效不理想。另外，中成药的有效成分含量太低，难以达到有效作用，实际上临床上应用，除非大剂量使用才可能有用。 大家知道，水煎中药，是一大包，而<a href='/topic/show?id=4c45222205b' target=_blank style='color:#2F92EE;'>#中成药#</a>，才几粒，能否有效，可想而知的，主要问题是剂量不够！, beContent=null, objectType=article, channel=null, level=null, likeNumber=319, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=29945, encryptionId=a92c29945eb, topicName=六味地黄丸), TopicDto(id=76760, encryptionId=b081e6760b8, topicName=糖尿病肾病), TopicDto(id=101869, encryptionId=e59810186916, topicName=骨质疏松症), TopicDto(id=22423, encryptionId=5c1d22423c8, topicName=中药), TopicDto(id=22220, encryptionId=4c45222205b, topicName=中成药)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Nov 05 14:03:14 CST 2020, time=2020-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1919136, encodeId=474f191913602, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Apr 23 17:11:23 CST 2021, time=2021-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592644, encodeId=d27d1592644de, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Sun Oct 04 15:11:23 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889824, encodeId=6c1988982408, content=看标题还以为真有效果呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00074131254, createdName=13c30453m58暂无昵称, createdTime=Sat Oct 03 08:25:32 CST 2020, time=2020-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043350, encodeId=07b510433501f, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Oct 03 03:11:23 CST 2020, time=2020-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889782, encodeId=efd9889e825c, content=图不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f804870411, createdName=1419516246, createdTime=Sat Oct 03 00:22:50 CST 2020, time=2020-10-03, status=1, ipAttribution=)]
    2020-10-03 1419516246

    图不错

    0