Plos Medicine:刷新认知!高脂乳制品摄入量越高,心血管越健康!

2021-10-09 生物探索 生物探索

来自哈佛大学、约翰霍普金斯大学、新南威尔士大学和乌普萨拉大学的研究人员进行的一项研究表明,相比之下,乳脂摄入量高的人患上心血管疾病的风险更小。

心血管疾病又被称为循环系统疾病,是一系列涉及循环系统的疾病,主要指高脂血症、血液黏稠、动脉粥样硬化、高血压等导致的心脏及血管疾病,一般情况下是由“三高”引起。据《中国心血管健康与疾病报告2020》指出,我国心血管疾病现患病人数3.3亿,并且仍处于持续上升阶段。所以,心血管疾病是一种迫切需要针对性治疗方案的疾病。

在以往的认知里,一提到心血管疾病,我们经常会把它跟高脂肪摄入过多联系起来,也正因为这样,很多膳食指南都建议减少全脂乳制品的摄入,而鼓励大家尤其是中老年人选择低脂乳制品。相信大家也会经常为家里的老年人购买低脂奶粉等低脂乳制品。但是低脂是真的对人体更好,更容易降低患上心血管疾病的风险吗?

最近,来自哈佛大学、约翰霍普金斯大学、新南威尔士大学和乌普萨拉大学的研究人员进行的一项研究,其结果让人大跌眼镜。这项研究表明,相比之下,乳脂摄入量高的人患上心血管疾病的风险更小。相关研究结果以“Biomarkers of dairy fat intake, incident cardiovascular disease, and all-cause mortality: A cohort study, systematic review, and meta-analysis”为题发表在Plos Medicine上。

(文献DOI:https://doi.org/10.1371/journal.pmed.1003763)

首先,研究人员明确了十五烷酸、十七烷酸以及反式棕榈油酸是乳脂摄入的生物标志物,使用它们能够准确测量出人体内的乳脂摄入量。这项研究中,研究人员分析了来自瑞典斯德哥尔摩的一个健康研究队列,包括4150名平均年龄为60岁的健康成年人,中位随访时间为16.6年,在此期间发生了578起心血管疾病事件和676例死亡。

研究人员收集了参与者的血液样本,并将血清样本储存在-80°C,测量其中的十五烷酸含量。在调整了年龄、性别、受教育程度、生活方式以及其他疾病等因素后,研究人员发现较高的十五烷酸含量与较低的心血管疾病发病率线性相关,当心血管疾病发生率较高时十五烷酸的水平较低。在二级分析中,较高的十五烷酸含量与较低的冠心病风险显着相关,但是与缺血性卒中无关。

(图注:十五烷酸含量与心血管疾病之间的关系)

由于十五烷酸是人体乳脂摄入量的生物标志物,十五烷酸含量越高也就代表着乳脂摄入量较高。因而以上实验也就说明,乳脂摄入量越高,心血管疾病发生率就越低。既然证明了乳脂摄入量与心血管疾病有关,那它与死亡风险之间又有什么样的关系呢?

同样的,研究人员调整了其他因素,发现十五烷酸含量与全因死亡率之间没有明显的相关性,也就说明较高的乳脂摄入量不会增加死亡风险。

(图注:十五烷酸与全因死亡率之间的关系)

总之,这项研究证明乳脂摄入量与心血管疾病患病率呈负相关,当乳脂摄入量较高时心血管疾病患病率较低,并且乳脂摄入量与全因死亡率之间并没有明确相关性。这也就说明,较高水平的乳脂摄入量对心血管是大有裨益的。希望可以早日开展临床研究,进而确定乳制品在预防心血管疾病方面的潜在作用。

原始出处:

Kathy Trieu, et al. Biomarkers of dairy fat intake, incident cardiovascular disease, and all-cause mortality: A cohort study, systematic review, and meta-analysis. Plos Medicine, 2021.

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    2021-11-11 kalseyzl
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    2022-02-01 lmm397
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    2022-03-25 jeanqiuqiu
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    2021-10-11 pcw111
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