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EASD 2013：常用降血糖药物不增加腺癌风险

2013-10-18 MedSci MedSci原创

降血糖腺癌EASD
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流行病学研究提示某些降血糖药物可能会增加或降低2型糖尿病患者癌症的风险。为了比较不同降血糖药物相关腺癌发生的风险，来自荷兰伊拉斯姆斯大学Airin Simon教授及其团队进行了一项研究，该研究发现常用降血糖药物对腺癌发生无影响。该研究结果发表在2013年EASD会议上。该研究中，在荷兰初级保健研究数据库（IPCI）1996-2011年期间的2型糖尿病患者（29383例）中间进行一项病例对照研究。入

流行病学研究提示某些降血糖药物可能会增加或降低2型糖尿病患者癌症的风险。为了比较不同降血糖药物相关腺癌发生的风险，来自荷兰伊拉斯姆斯大学Airin Simon教授及其团队进行了一项研究，该研究发现常用降血糖药物对腺癌发生无影响。该研究结果发表在2013年EASD会议上。【原文下载】


该研究中，在荷兰初级保健研究数据库（IPCI）1996-2011年期间的2型糖尿病患者（29383例）中间进行一项病例对照研究。入选首次诊断为结直肠癌、乳腺癌、前列腺或胰腺癌的病例，以及30例对照组病例（每例与腺癌病例年龄、性别、糖尿病病程和随访时间相匹配）。使用条件logistic回归分析计算比值比（OR）和95%可信区间（CI）。同时，将索引日期向后前移两年进行重复分析。

该研究结果表明，共确定了702例腺癌患者，平均年龄64.9±11.8岁。与饮食对照组相比，二甲双胍单药治疗组对腺癌发生没有影响。 而且，与二甲双胍单药治疗相比，磺脲类药物单药治疗并不导致腺癌发生风险显著增加。同样，当与二甲双胍单药治疗相比，磺脲类药物联合二甲双胍、胰岛素联合二甲双胍、或者磺脲类药物、胰岛素和二甲双胍三者联用与腺癌发生风险增加无关。此外，将索引日期时间前移并不能导致结果发生太大的变化。

该研究的结果并未发现常用降血糖药物会增加或减少腺癌发生风险。


原文检索：
A.C.R. Simon, G.W. 't Jong, V.E. Valkhoff, M. Sturkenboom, J.B.L. Hoekstra, F. Holleman; Use of glucose lowering drugs and the risk of adenocarcinoma among patients with type 2 diabetes: a case-control study in the Netherlands.【原文下载】



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    2014-03-28 sjq027

    #癌风险#

    0

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    2013-12-19 okhuali

    #ASD#

    0

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    2014-02-07 yangeasy

    #降血糖#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2061403, encodeId=58df2061403f8, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Fri Mar 28 06:32:00 CST 2014, time=2014-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1690577, encodeId=bb0516905e7f1, content=<a href='/topic/show?id=5c472843a1' target=_blank style='color:#2F92EE;'>#ASD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2843, encryptionId=5c472843a1, topicName=ASD)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4e8529069357, createdName=okhuali, createdTime=Thu Dec 19 06:32:00 CST 2013, time=2013-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1648727, encodeId=94b01648e27de, content=<a href='/topic/show?id=79ad9820ef7' target=_blank style='color:#2F92EE;'>#降血糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98207, encryptionId=79ad9820ef7, topicName=降血糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a53c23663172, createdName=yangeasy, createdTime=Fri Feb 07 01:32:00 CST 2014, time=2014-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1534071, encodeId=5fa315340e1cb, content=<a href='/topic/show?id=576e643634' target=_blank style='color:#2F92EE;'>#EASD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6436, encryptionId=576e643634, topicName=EASD)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21f812527653, createdName=qilu_qi, createdTime=Sun Oct 20 05:32:00 CST 2013, time=2013-10-20, status=1, ipAttribution=)]
    2013-10-20 qilu_qi

    #EASD#

    0