ASCO 2014:老年患者结直肠癌相关并发症

2014-06-09 ruanancy 译 医学论坛网

老年癌症患者的综合护理管理于上周六下午3:00-4:15在E451b举行的肿瘤学临床问题分会“老年结直肠癌相关并发症的治疗”上被重点讨论。 斯隆凯特林癌症纪念中心的医学博士Mario E. Lacouture将介绍结直肠癌新靶向药物所带来的皮肤病问题;Dr. Lacouture指出,即使是在癌症未经治疗的情况下,老年患者发生皮肤病症状的频率也较高,因为衰老的皮肤失去了快速自我修复

老年癌症患者的综合护理管理于上周六下午3:00-4:15在E451b举行的肿瘤学临床问题分会“老年结直肠癌相关并发症的治疗”上被重点讨论。



斯隆凯特林癌症纪念中心的医学博士Mario E. Lacouture将介绍结直肠癌新靶向药物所带来的皮肤病问题;Dr. Lacouture指出,即使是在癌症未经治疗的情况下,老年患者发生皮肤病症状的频率也较高,因为衰老的皮肤失去了快速自我修复和以正常速率生长的能力;他说道,添加应用癌症疗法会对那些皮肤已因终生暴晒和衰老而被破坏的患者带来各种特殊问题,这意味着,这些患者的皮肤受损后修复能力下降,更易感发生各种炎性或感染性疾病。

老年患者的皮肤比较干燥、易发痒;脚部发生真菌感染和头皮发生脱发的几率较高。Dr. Lacouture认为,应用靶向疗法治疗结直肠癌会引起“皮肤毒性的集聚”。他是一名专门研究癌症疗法各种不良事件的皮肤科医生。

EGFR抑制剂如西妥昔单抗和帕尼单抗无论是单独应用还是与其它药物联用都会造成患者面部和胸部发生痤疮样皮疹;虽然该皮疹不会致残,但却会对患者的生活质量造成影响。“我曾经看到过一些成年人就因为这皮疹而伤心流泪,他们不愿意出门,不仅仅是因为疼痛,还因为这皮疹太影响形象。不过幸运的是,绝大部分这样的情况都是可预防的。” Dr. Lacouture说到。

另一种疗法——氟尿嘧啶——可引起手足综合征,该病的特点是手掌和脚底疼痛。靶向疗法会使皮肤变得非常干燥、瘙痒,患者因此要反复抓挠,甚至会因不适而无法入眠。瑞戈非尼是最近刚被批准用于结肠癌治疗的一种靶向药物,可导致患者手脚发生疼痛性水泡,影响患者手脚运用、行走能力。

“老年患者对这些不良事件的耐受能力较差,” Dr. Lacouture说,“如果老年人因这些不良事件而致残、行动不便,这就是个大问题了。他们的身体会失去平衡,容易摔倒,他们的生活质量会受到极大的影响。”

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    2015-03-02 xiaoai5777

    好文章,超赞

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    2014-06-19 丁鹏鹏
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    2014-10-04 quxin068
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