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SCI REP：血浆同型半胱氨酸浓度与脑出血风险！

2018-02-07 xing.T MedSci原创

血浆Hcy脑出血风险
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总之，Hcy水平可能是动脉粥样硬化的加重因素，与ICH的高风险呈正相关。亚洲人和白种人的种族差异对ICH的风险没有影响。

颅内出血（ICH）是所有卒中患者中死亡率最高的一种类型。然而，血浆中同型半胱氨酸（Hcy）与ICH之间的关系仍存在争议。近日，Scientific reports 杂志上针对这一问题发表了一篇荟萃分析文章。

研究人员检索了PubMed、Embase、Web of Science等数据库，检索时间截止至2017年4月18日。研究人员计算了血浆同型半胱氨酸水平平均差异的标准平均差（SMD）和95%可信区间（CI）。

该荟萃分析共纳入了七项研究，包括667名ICH患者和1821名缺血性卒中患者。研究人员发现，ICH患者Hcy水平明显高于正常对照组（SMD=0.59，95%CI为0.51-0.68，P＜0.001）ICH患者与缺血性脑卒中患者之间的Hcy的水平比较无统计学差异（SMD=-0.03，95%CI为-0.13至-0.06，P＞0.05）； 进一步亚组分析发现种族（亚洲人：SMD=0.57，95%CI为0.48-0.66，P＜0.001；白种人：SMD=0.77，95%CI为0.51-1.02，P<0.001）和样本大小（小样本：SMD=0.55，95%CI为0.30-0.80，P＜0.001；大样本：SMD=0.60，95%CI为0.51-0.69，P＜0.001）与ICH患者和健康对照者之间Hcy水平的相关性没有改变这些结果。

总之，Hcy水平可能是动脉粥样硬化的加重因素，与ICH的高风险呈正相关。亚洲人和白种人的种族差异对ICH的风险没有影响。

原始出处：

Zhike Zhou,et al. Plasma homocysteine concentrations and risk of intracerebral hemorrhage: a systematic review and meta-analysis.Scientific reports. 2018. https://www.nature.com/articles/s41598-018-21019-3

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    2018-02-09 12498974m55暂无昵称

    #浓度#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1544503, encodeId=88211544503bf, content=<a href='/topic/show?id=ac3d6549e75' target=_blank style='color:#2F92EE;'>#浓度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65497, encryptionId=ac3d6549e75, topicName=浓度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16b213663040, createdName=12498974m55暂无昵称, createdTime=Fri Feb 09 13:05:00 CST 2018, time=2018-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286136, encodeId=5aca28613638, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Thu Feb 08 06:08:52 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286126, encodeId=63f4286126b3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Thu Feb 08 05:52:46 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286117, encodeId=895928611e3a, content=非常好.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/21/9461f3b3c9f14e1d844256cdd08f2cf3.jpg, createdBy=a30f1426910, createdName=swfzhanggui, createdTime=Thu Feb 08 05:34:27 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286073, encodeId=e60d2860e38e, content=学习了.有用.期望进一步研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Wed Feb 07 23:43:17 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286067, encodeId=af8328606e53, content=颅内出血(ICH)是所有卒中患者中死亡率最高的一种类型.然而.血浆中同型半胱氨酸(Hcy)与ICH之间的关系仍存在争议.近日.Scientificreports杂志上针对这一问题发表了一篇荟萃分析文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Wed Feb 07 23:32:05 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286048, encodeId=ab662860488b, content=是很好的学习材料.不错.以后会多学习., beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Wed Feb 07 22:46:53 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286037, encodeId=3aa128603e99, content=同型半胱氨酸动脉硬化的很重要指标之一., beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Feb 07 22:13:13 CST 2018, time=2018-02-07, status=1, ipAttribution=)]
    2018-02-08 121832a9m88暂无昵称

    学习了

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1544503, encodeId=88211544503bf, content=<a href='/topic/show?id=ac3d6549e75' target=_blank style='color:#2F92EE;'>#浓度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65497, encryptionId=ac3d6549e75, topicName=浓度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16b213663040, createdName=12498974m55暂无昵称, createdTime=Fri Feb 09 13:05:00 CST 2018, time=2018-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286136, encodeId=5aca28613638, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Thu Feb 08 06:08:52 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286126, encodeId=63f4286126b3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Thu Feb 08 05:52:46 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286117, encodeId=895928611e3a, content=非常好.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/21/9461f3b3c9f14e1d844256cdd08f2cf3.jpg, createdBy=a30f1426910, createdName=swfzhanggui, createdTime=Thu Feb 08 05:34:27 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286073, encodeId=e60d2860e38e, content=学习了.有用.期望进一步研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Wed Feb 07 23:43:17 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286067, encodeId=af8328606e53, content=颅内出血(ICH)是所有卒中患者中死亡率最高的一种类型.然而.血浆中同型半胱氨酸(Hcy)与ICH之间的关系仍存在争议.近日.Scientificreports杂志上针对这一问题发表了一篇荟萃分析文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Wed Feb 07 23:32:05 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286048, encodeId=ab662860488b, content=是很好的学习材料.不错.以后会多学习., beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Wed Feb 07 22:46:53 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286037, encodeId=3aa128603e99, content=同型半胱氨酸动脉硬化的很重要指标之一., beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Feb 07 22:13:13 CST 2018, time=2018-02-07, status=1, ipAttribution=)]
    2018-02-08 秀红

    学习了

    0

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    2018-02-08 swfzhanggui

    非常好.谢谢分享

    0

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    2018-02-07 明崖

    学习了.有用.期望进一步研究

    0

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    2018-02-07 有备才能无患

    颅内出血(ICH)是所有卒中患者中死亡率最高的一种类型.然而.血浆中同型半胱氨酸(Hcy)与ICH之间的关系仍存在争议.近日.Scientificreports杂志上针对这一问题发表了一篇荟萃分析文章

    0

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    2018-02-07 李东泽

    是很好的学习材料.不错.以后会多学习.

    0

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    2018-02-07 1e0f8808m18(暂无匿称)

    同型半胱氨酸动脉硬化的很重要指标之一.

    0