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Sci Rep：新型生物材料可有效促进神经再生

2018-01-21 MedSci MedSci原创

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周围神经损伤的外科重建仍然是一个难题。许多研究集中在探究合成或使用生物材料制成的人造神经导管，但理想的方法尚未确定。在这里，研究人员使用一种新型可生物降解水凝胶（专利是氧化聚乙烯醇（OxPVA））制造了周围神经再生的导管。通过体外和体内分析比较了纯聚乙烯醇（PVA）和丝素（SF）管道的特性。 结果显示，与SF不同，OxPVA和纯PVA支架在体外不支持SH-SY5Y粘附和增殖。在坐骨神经切断大鼠模型

周围神经损伤的外科重建仍然是一个难题。许多研究集中在探究合成或使用生物材料制成的人造神经导管，但理想的方法尚未确定。在这里，研究人员使用一种新型可生物降解水凝胶（专利是氧化聚乙烯醇（OxPVA））制造了周围神经再生的导管。

通过体外和体内分析比较了纯聚乙烯醇（PVA）和丝素（SF）管道的特性。 结果显示，与SF不同，OxPVA和纯PVA支架在体外不支持SH-SY5Y粘附和增殖。在坐骨神经切断大鼠模型中植入后，12周时，三条导管支持损伤神经再生，填充5mm的间隙。植入的动物显示出良好的步态恢复。与移植管道的中心部分有关的形态测量数据结果显示，与PVA导管及自体移植组相比，OxPVA支架轴突密度明显更好。

综上所述，该研究结果表明，此新型生物材料或可用于临床周围神经病变缺损的修复。

原始出处：

Elena Stocco, Silvia Barbon, et al., Partially oxidized polyvinyl alcohol conduitfor peripheral nerve regeneration. Sci Rep. 2018; 8: 604. doi:  10.1038/s41598-017-19058-3

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    2018-10-20 1249857fm32暂无昵称

    #生物材#

    0

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    2018-01-23 dongjia2013

    #生物材料#

    0

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    2018-01-23 hxj0121

    #神经再生#

    0

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    2018-01-21 惠映实验室

    学习..谢谢分享.

    0

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    2018-01-21 惠映实验室

    学习..谢谢分享.

    0

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    2018-01-21 131****1460

    学习了受益匪浅

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