Sci Rep:研究首次合成活性重组血浆磷脂转运蛋白可有效治疗内毒素血症和败血症

2017-10-03 MedSci MedSci原创

既往大部分关于血浆磷脂转运蛋白(PLTP)的研究主要集中于动脉粥样硬化,但它与参与先天免疫的蛋白质具有同源性。本研究中,研究人员在转基因兔新品种的牛奶中制备了活性重组人PLTP(rhPLTP)。成功地使用rhPLTP作为外源性治疗蛋白来治疗内毒素血症和败血症。 在注射纯化的脂多糖或多微生物感染的小鼠模型中,研究人员证明rhPLTP可以防止细菌生长,并可解除LPS的毒性。为了进一步研究证实PLTP的

既往大部分关于血浆磷脂转运蛋白(PLTP)的研究主要集中于动脉粥样硬化,但它与参与先天免疫的蛋白质具有同源性。本研究中,研究人员在转基因兔新品种的牛奶中制备了活性重组人PLTP(rhPLTP)。成功地使用rhPLTP作为外源性治疗蛋白来治疗内毒素血症和败血症。

在注射纯化的脂多糖或多微生物感染的小鼠模型中,研究人员证明rhPLTP可以防止细菌生长,并可解除LPS的毒性。为了进一步研究证实PLTP的抗菌作用,研究人员发现PLTP敲除的小鼠比野生型小鼠能够更好的抗击败血症。

总之,该研究首次报道了生产rhPLTP,并将其用于抵抗感染和减少内毒素血症及其有害的后果。 这为日后研发新的治疗策略铺平了道路,以满足长期以来尚未满足的预防和治疗败血症的需求。

原始出处:


Valérie Deckert, Stéphanie Lemaire, et al., Recombinant human plasma phospholipid transfer protein (PLTP) to prevent bacterial growth and to treat sepsis. Sci Rep. 2017; 7: 3053. Published online 2017 Jun 8. doi: 10.1038/s41598-017-03285-9

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    2017-10-03 往日如昨

    继续学习中谢谢

    0

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    2017-10-03 往日如昨

    学习了谢谢分享

    0

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    2017-10-03 1e0f8808m18(暂无匿称)

    好文章.学习了.

    0

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    2017-10-03 thlabcde

    好资料学习了!

    0

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    2017-10-03 榄枷檬

    谢谢分享

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1696296, encodeId=a1a7169629682, content=<a href='/topic/show?id=0107934e0a5' target=_blank style='color:#2F92EE;'>#转运#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93470, encryptionId=0107934e0a5, topicName=转运)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47c429881595, createdName=yzh409, createdTime=Fri Aug 03 06:32:00 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1704190, encodeId=28031e04190c3, content=<a href='/topic/show?id=172330400dd' target=_blank style='color:#2F92EE;'>#内毒素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30400, encryptionId=172330400dd, topicName=内毒素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue Aug 28 15:32:00 CST 2018, time=2018-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1572951, encodeId=a2d115e2951f4, content=<a href='/topic/show?id=62fa3040356' target=_blank style='color:#2F92EE;'>#内毒素血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30403, encryptionId=62fa3040356, topicName=内毒素血症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=417b15789705, createdName=rgjl, createdTime=Wed Oct 04 15:32:00 CST 2017, time=2017-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619489, encodeId=03ab16194896a, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Wed Oct 04 15:32:00 CST 2017, time=2017-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249965, encodeId=f2b5249965ea, content=继续学习中谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Tue Oct 03 10:13:21 CST 2017, time=2017-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249964, encodeId=ff23249964fd, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Tue Oct 03 10:13:17 CST 2017, time=2017-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249940, encodeId=97832499405f, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Tue Oct 03 08:45:40 CST 2017, time=2017-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249896, encodeId=ca0c24989692, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Oct 03 07:27:32 CST 2017, time=2017-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249891, encodeId=4e8b249891ed, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Tue Oct 03 07:15:29 CST 2017, time=2017-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249880, encodeId=9898249880d1, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Oct 03 07:01:58 CST 2017, time=2017-10-03, status=1, ipAttribution=)]
    2017-10-03 龙胆草

    学习谢谢分享

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