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PNAS：首次发现神秘力量支撑长时间分娩宫缩！

2015-08-14 佚名 生物探索

宫缩产妇
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众所周知，催产素能够在分娩时刺激子宫收缩，能够帮助婴儿顺利通过产道。由于紧缩的肌肉会挤压到血管导致血液流动受阻、氧气含量降低，按照正常生理规律，宫缩过程应会减弱。然而分娩过程中子宫肌肉却能维持长时间收缩，除了激素等外力作用，是否还存在其他动力呢？为解开这一谜题，利物浦转化医学研究所Susan Wray教授带领博士后研究人员Sarah Arrowsmith、博士Mohammed Alotaibi对子

众所周知，催产素能够在分娩时刺激子宫收缩，能够帮助婴儿顺利通过产道。由于紧缩的肌肉会挤压到血管导致血液流动受阻、氧气含量降低，按照正常生理规律，宫缩过程应会减弱。然而分娩过程中子宫肌肉却能维持长时间收缩，除了激素等外力作用，是否还存在其他动力呢？

为解开这一谜题，利物浦转化医学研究所Susan Wray教授带领博士后研究人员Sarah
Arrowsmith、博士Mohammed Alotaibi对子宫收缩机制进行研究。相关研究成果发表于the journal Proceedings of the National Academy of Sciences。

研究团队进行了系统试验发现，即便中断催产素的注射，肌肉收缩过程还是会逐渐增强。这就意味着，催产素虽然起到作用，但绝不是分娩过程中促进子宫肌肉收缩的唯一贡献者。

建立在这个结果上，研究人员继续挖掘持续宫缩的“力量来源”。他们注意到心脏研究中会对其肌肉细胞进行缺氧预处理，以避免细胞受到极度缺氧的伤害。这种预处理能在紧急状况下拯救生命。

顺着这一线索，研究人员发现一种保护子宫肌肉的机制——低氧诱导力增强（HIFI），这种机制能够在子宫面临反复性缺乏血液和氧气供应的情况下，促进子宫收缩进行自我保护。这是一个正反馈调节过程：肌肉重复性收缩，氧气下降，收缩频率增强。

试验过程中，一旦HIFI机制启动，能够维持数小时，时间与实际分娩一样。这种机制是支撑长时间分娩的关键，增加紧急剖腹产的婴儿存活几率。Wray教授表示，这是一个惊奇的发现，不仅扩充了科学家们对生物系统响应低氧状态的认知，还为医生应对难产等分娩困难提供了新的解决思路。

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    2015-12-20 drwjr

    #PNAS#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1855769, encodeId=e4231855e6970, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Sun Dec 20 00:21:00 CST 2015, time=2015-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1743689, encodeId=c19e1e436899b, content=<a href='/topic/show?id=0cb1462e7c3' target=_blank style='color:#2F92EE;'>#宫缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46277, encryptionId=0cb1462e7c3, topicName=宫缩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c34935182975, createdName=windight, createdTime=Wed Sep 02 22:21:00 CST 2015, time=2015-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37707, encodeId=1ada3e70777, content=神秘力量～～～, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=754a1652870, createdName=1ddcfa8bm07(暂无匿称), createdTime=Mon Oct 05 15:43:00 CST 2015, time=2015-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35691, encodeId=a7ba35691f6, content=神秘力量, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Sun Aug 16 18:37:00 CST 2015, time=2015-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35684, encodeId=6d5e35684ff, content=好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Sun Aug 16 11:33:00 CST 2015, time=2015-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275065, encodeId=ff8212e5065bb, content=<a href='/topic/show?id=263031541b4' target=_blank style='color:#2F92EE;'>#分娩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31541, encryptionId=263031541b4, topicName=分娩)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d590125, createdName=linlin2312, createdTime=Sun Aug 16 05:21:00 CST 2015, time=2015-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35594, encodeId=94e13559413, content=这个研究的思路非常不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Aug 14 21:17:00 CST 2015, time=2015-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35567, encodeId=ef8b3556ece, content=是真的吗？, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=126b110623, createdName=ndd99, createdTime=Fri Aug 14 17:01:00 CST 2015, time=2015-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35563, encodeId=caea35563c2, content=厉害了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Fri Aug 14 16:01:00 CST 2015, time=2015-08-14, status=1, ipAttribution=)]
    2015-09-02 windight

    #宫缩#

    0

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    2015-10-05 1ddcfa8bm07(暂无匿称)

    神秘力量～～～

    0

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    2015-08-16 cmn

    神秘力量

    0

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    2015-08-16 stupidox

    好！

    0

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    2015-08-16 linlin2312

    #分娩#

    0

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    2015-08-14 medcardio

    这个研究的思路非常不错

    0

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    2015-08-14 ndd99

    是真的吗？

    0

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    2015-08-14 lovejing

    厉害了

    0