Thyroid:碘摄入与甲状腺抗体之间的关系

2020-06-27 MedSci原创 MedSci原创

甲状腺抗体阳性率仍然很低。MAI和EI与TPOAb阳性呈负相关,这表明100μg/L至299μg/L的UIC对甲状腺自身免疫是最佳且安全的。这些结论需要在后续研究中进一步证实,因为该研究是横断面研究。

碘摄入与甲状腺自身免疫有关。近日,甲状腺疾病领域权威杂志Thyroid上发表了一篇研究文章,这项研究旨在评估了中国20年普遍食盐加碘(USI)后甲状腺自身免疫的变化。

来自中国大陆31个省的78470名受试者(年龄18岁或以上)参加了这项研究。研究人员测量了受试者的血清甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb)、TSH受体抗体(TRAb)、甲状腺刺激激素(TSH)和尿碘浓度(UIC)。

研究人员分别在10.19%(95%CI为9.80%至10.59%)和9.70%(95%CI为9.28%至10.13%)的受试者中检测到TPOAb和TgAb阳性。阳性分离的TPOAb(i-TPOAb)、阳性分离的TgAb(i-TgAb)以及双重阳性TPOAb和TgAb(d-Ab)的患病率分别为4.52%、4.16%和5.94%。在缺碘(UIC<100 µg/L)组中,甲状腺抗体阳性率最高。i-TPOAb的患病率与超量碘摄入(MAI)和过量碘摄入(EI)成反比。MAI的比值比(OR)为0.89(95%CI为0.81-0.98),EI的比值比为0.90(95%CI为0.81-0.99)。研究人员观察到,与i-TPOAb一样,i-TgAb是TSH水平降低(OR=3.64,95%CI为2.62-5.05)和TSH水平升高(OR=1.62,95%CI为1.49-1.77)的高风险因素。在五个民族中,甲状腺抗体阳性的发生率有所不同。

经过20年的USI,甲状腺抗体阳性率仍然很低。MAI和EI与TPOAb阳性呈负相关,这表明100μg/L至299μg/L的UIC对甲状腺自身免疫是最佳且安全的。这些结论需要在后续研究中进一步证实,因为该研究是横断面研究。

原始出处:

Di Teng,et al.An inverse relationship between iodine intake and thyroid antibodies: a national cross-sectional survey in mainland China.Thyroid.2020.https://www.liebertpub.com/doi/10.1089/thy.2020.0037

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    2021-05-11 carrotlyl

    谢谢

    0

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    2021-05-06 MedSciZeng

    #Thyroid#点击进入话题查看更多相关文章 或评论时插入话题加入讨论

    0

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    2020-12-28 ms6000000854809298

    学习了

    0

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    2020-06-29 songbq
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    2020-06-29 songbq

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