Eur Heart J-Card Img:升主动脉中钙化进展与心血管疾病事件呈负相关

2018-02-11 xing.T MedSci原创

由此可见,胸腔升主动脉钙化在连续性心脏CT上并不常见。然而,ATAC体积和密度的变化都与ASCVD事件发生有关,但方向相反。对于基线ATAC进行系列评估可以了解个体发生ASCVD风险的轨迹。

随着时间推移胸升主动脉钙(ATAC)的体积和密度的变化所引起的动脉粥样硬化性心血管疾病(ASCVD)风险所知甚少。近日,心血管领域权威杂志Eur Heart J-Card Img上发表了一篇研究文章,研究人员评估了ATAC体积和密度评分改变与ASCVD事件发生之间的相关性。

动脉粥样硬化的多民族研究是一项无基础临床ASCVD个体中进行的前瞻性队列研究。研究人员采用心脏计算机断层扫描(CT)测量了基线和随访(平均间隔2.4年)后升主动脉钙化情况。在调整ASCVD危险因素、基线ATAC和冠状动脉钙化(CAC)体积和密度以及CAC体积和密度变化值后,研究人员使用Cox比例风险回归估计了随访后事件发生的风险比(HR)和95%可信区间(CI)。

在5887名参与者中,有296名(5.0%)在基线、随访或两次检查中均可检测到ATAC。9.5年来共发生了403起事件。ATAC体积增加与冠心病(CHD)(HR为1.90,95%CI为1.14-3.16)、ASCVD(HR为1.93,95%CI为1.26-2.94)和缺血性卒中(HR为2.14,95%CI为1.21-3.78)相关。ATAC密度的增加与CHD(HR为0.29,95%CI为0.14-0.60)和ASCVD(HR为0.42,95%CI为0.23-0.76)呈负相关,而与卒中无关(HR为0.61,95%CI为0.23-1.61)。

由此可见,胸腔升主动脉钙化在连续性心脏CT上并不常见。然而,ATAC体积和密度的变化都与ASCVD事件发生有关,但方向相反。对于基线ATAC进行系列评估可以了解个体发生ASCVD风险的轨迹。

原始出处:

Isac C Thomas,et al. Progression of calcium density in the ascending thoracic aorta is inversely associated with incident cardiovascular disease events. Eur Heart J-Card Img. 2018. https://doi.org/10.1093/ehjci/jex011

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    2018-02-18 天涯183

    非常好的文章.学习了

    0

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    2018-02-13 zhaojie88
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    2018-02-13 slcumt
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    2018-02-13 hmwwww