Materials:3D打印生物玻璃和β-磷酸三钙骨支架可较好的促进成骨

2018-01-24 MedSci MedSci原创

由于材料的高生物相容性和植入体内后的吸收能力,目前已广泛使用生物玻璃(BG)和β磷酸三钙(β-TCP)进行骨替换。关于3D打印制造多孔骨支架的快速和多功能技术已经进行了探索。本研究旨在探究使用3D打印不同组合的复合BG和β-TCP粉末的多孔骨支架的影响。研究对BG、β-TCP、50/50 BG/β-TCP和70/30 BG/β-TCP复合物的多孔3D粉末印刷的骨支架进行各种表征和生物相容性测试。评

由于材料的高生物相容性和植入体内后的吸收能力,目前已广泛使用生物玻璃(BG)和β磷酸三钙(β-TCP)进行骨替换。关于3D打印制造多孔骨支架的快速和多功能技术已经进行了探索。本研究旨在探究使用3D打印不同组合的复合BG和β-TCP粉末的多孔骨支架的影响。

研究对BG、β-TCP、50/50 BG/β-TCP和70/30 BG/β-TCP复合物的多孔3D粉末印刷的骨支架进行各种表征和生物相容性测试。评估孔隙率特征、表面粗糙度、机械强度、细胞增殖活力、材料细胞毒性和体外生物活性。

结果表明,支架材料可以在支架材料表面和支架材料内部支持成骨样细胞MG-63生长,且无明显的细胞毒性,支架的孔隙率和表面特性合适。在两种测试的复合材料中,70/30 BG/β-TCP支架在生物相容性和机械强度方面优异。虽然支架的机械强度并不适用于承重应用,但是,其可用于其他方面的治疗,如作为骨填充剂使用。

原始出处:

Seidenstuecker M, Kerr L, et al., 3D Powder Printed Bioglass and β-Tricalcium Phosphate Bone Scaffolds. Materials (Basel). 2017 Dec 22;11(1). pii: E13. doi: 10.3390/ma11010013.

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    2018-01-26 zhaojie88
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    2018-01-26 lixiaol
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    2018-01-26 lixiaol