拉莫三嗪口腔崩解片患者体验优于其速释片

　　拉莫三嗪一种抗癫痫药，可用于双相I型及各种类型癫痫的治疗。拉莫三嗪口腔崩解片（ODT）作为一种剂型选择，或可提高患者用药的满意度和方便度。

　　近期刊登于PubMed网络版的一项前瞻性开放研究对拉莫三嗪两种剂型的患者用药的满意度和方便度进行了评估。受试者普遍认为拉莫三嗪ODT明显比其速释剂型更方便服用，同时，受试者对两种剂型的满意度均较高。研究者指出拉莫三嗪ODT或可作为药物吞咽困难患者一个治疗选择。

　　参与研究的受试者为近期接受拉莫三嗪治疗的存在吞咽困难现象的情绪障碍患者（基线）。受试者接受了为期三周的拉莫三嗪ODT治疗。使用药物治疗满意度调查问卷（TSQM）评价受试者用药的满意度和方便度，使用临床总体印象严重程度量表（CGI-S）对总体精神病理学进行评估，患者的抑郁症状通过白氏抑郁量表（BDI-II）进行评估。

　　研究发现，拉莫三嗪ODT与速释片相比明显更方便患者服用（基线TSQM方便度评分改变：23.3，n=97，P<0.001)。平均TSQM整体满意度评分与基线（76.3）接近，拉莫三嗪ODT治疗后该评分为76.0。CGI-S与BDI-II无显著改变。

Prospective, open-label trial measuring satisfaction and convenience of two formulations of lamotrigine in subjects with mood disorders.
BACKGROUND
Lamotrigine is an anticonvulsant drug indicated for the maintenance treatment of bipolar I disorder and for various types of epilepsy. An orally disintegrating tablet (ODT) of lamotrigine was developed to provide a formulation option that might increase patient convenience and satisfaction.
METHODS
Subjects with mood disorders who reported difficulty swallowing currently prescribed lamotrigine immediate-release medication (baseline) were enrolled and treated with lamotrigine ODT for three weeks (end of treatment). Subject satisfaction and convenience were measured using the Treatment Satisfaction Questionnaire for Medication (TSQM). Also measured were global psychopathology using the Clinical Global Impression severity index (CGI-S) and depressive symptoms using the Beck Depression Inventory (BDI-II).
RESULTS
Lamotrigine ODT was found to be significantly more convenient to use than lamotrigine immediate-release (change in baseline TSQM convenience score: 23.3, n = 97, P < 0.001). The mean TSQM global satisfaction score was similar at baseline (76.3) and after treatment with lamotrigine ODT (76.0). There were no significant changes on CGI-S and BDI-II.
CONCLUSION
Subjects reported that lamotrigine ODT was significantly more convenient than lamotrigine immediate-release, while both formulations were associated with good satisfaction. Lamotrigine ODT may be a treatment option for patients who have difficulty swallowing medication.