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梅奥：非梗阻性肥厚性心肌病的自然史

2016-03-26 MedSci MedSci原创

梅奥非梗阻型肥厚性心肌病
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为了描述一个大型的非梗阻性肥厚性心肌病(NO-HCM)队列研究的生存率并识别人群死亡率增加的危险因素。进行了一项回顾性观察研究，

为了描述一个大型的非梗阻性肥厚性心肌病(NO-HCM)队列研究的生存率并识别人群死亡率增加的危险因素。进行了一项回顾性观察研究，病人识别自1975年1月1日-2006年12月30日梅奥诊所HCM数据库。有静止性或活动性左室流出道阻塞的病人被排除在外。比较亚组间的超声心动图、临床和基因数据，比较预期人口比例与生存率。

总共识别了706个NO-HCM病人。中位随访时间5年（平均7年），208人死亡。匹配美国白人的年龄和性别的死亡率后整体生存率无差异(P=.77)。死亡独立预测因子包括诊断年龄、“爆发”HCM、短暂性脑缺血发作或卒中；使用可置入心脏转复除颤器（ICD）与死亡率负相关。排除ICD病人后，匹配年龄和性别的生存率无差异(P=.39)；年龄，之前发生TIA/卒中，和爆发的HCM是死亡的预测因子。

在这个队列中，患有NO-HCM的病人生存率与匹配美国白人年龄和性别的死亡率后相似。尽管使用ICD与死亡负相关，在排除此类病人后，整体生存率无差异。爆发HCM与死亡风险独立相关，识别了亚组中能够从更加具有侵略性治疗中获益的病人。

原始出处：

Virginia B. Hebl, William R. Miranda,Kevin C. Ong,et al,The Natural History of Nonobstructive Hypertrophic Cardiomyopathy,mayo clinic pro,2016


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    2016-12-22 mgqwxj

    #非梗阻性#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1819440, encodeId=e762181944042, content=<a href='/topic/show?id=ecb69948913' target=_blank style='color:#2F92EE;'>#非梗阻性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99489, encryptionId=ecb69948913, topicName=非梗阻性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=669d219, createdName=mgqwxj, createdTime=Thu Dec 22 23:23:00 CST 2016, time=2016-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1997391, encodeId=bf88199e3917e, content=<a href='/topic/show?id=67ec86244b1' target=_blank style='color:#2F92EE;'>#自然史#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86244, encryptionId=67ec86244b1, topicName=自然史)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ced3193, createdName=freve, createdTime=Sun Sep 18 19:23:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74269, encodeId=43aae4269f4, content=抱歉，不太懂, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3a411691127, createdName=1de5aaa9m95(暂无匿称), createdTime=Mon Mar 28 22:35:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368254, encodeId=5cfd13682547f, content=<a href='/topic/show?id=8a5e6242257' target=_blank style='color:#2F92EE;'>#梅奥#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62422, encryptionId=8a5e6242257, topicName=梅奥)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Mar 28 12:23:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622232, encodeId=ca40162223217, content=<a href='/topic/show?id=b9578094833' target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Mar 28 12:23:00 CST 2016, time=2016-03-28, status=1, ipAttribution=)]
    2016-09-18 freve

    #自然史#

    0

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    2016-03-28 1de5aaa9m95(暂无匿称)

    抱歉，不太懂

    0

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    2016-03-28 cmj8wellington

    #梅奥#

    0

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    2016-03-28 爆笑小医

    #肌病#

    0

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