J CLIN ONCOL:吸烟影响胰腺癌患者生存

2017-03-31 MedSci MedSci原创

胰腺癌诊断后大部分患者存活期不到12个月。除了疾病分期外,其他的预后因素研究较少。吸烟会增加胰腺癌的发病风险,与约20%的胰腺癌进展有关。但是很少有研究关注吸烟与胰腺癌患者生存之间的关系。

胰腺癌诊断后大部分患者存活期不到12个月。除了疾病分期外,其他的预后因素研究较少。吸烟会增加胰腺癌的发病风险,与约20%的胰腺癌进展有关。但是很少有研究关注吸烟与胰腺癌患者生存之间的关系。

J CLIN ONCOL近期报道了一篇文章研究吸烟对胰腺癌患者生存的影响。作者分析了1986-2013年之间确诊的胰腺癌患者吸烟情况。在485例患者中评估诊断前循环可替宁(与香烟暴露成比例的尼古丁代谢产物)水平对生存的影响。根据诊断前可替宁水平将患者分为不吸烟者(<3.1ng/ml),轻度吸烟者(3.1-20.9ng/ml)以及重度吸烟者(≥21.0nk/ml)。使用Cox比例风险模型评估死亡风险比(HRs)。研究结果表明与不吸烟患者相比,吸烟患者的死亡风险比为1.37(P=0.003)。随着吸烟量增加患者生存下降。戒烟患者与不吸烟患者生存情况相似。与不吸烟患者相比,根据诊断前循环可替宁水平判定为重度吸烟患者的死亡风险比为1.76。在确诊前5年内评估循环可替宁水平的患者中,重度吸烟患者的死亡风险是不吸烟患者的2.47倍。

作者最后得出结论,吸烟与胰腺癌患者生存下降有关。

原始出处:
Chen Yuan,Vicente Morales-Oyarvide,et al.Cigarette Smoking and Pancreatic Cancer Survival.J CLIN ONCOL.March 30 2017 doi:10.1200/JCO.2016.71.2026

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    2017-08-28 minlingfeng
  2. [GetPortalCommentsPageByObjectIdResponse(id=1864868, encodeId=8122186486895, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Aug 28 07:37:00 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1932561, encodeId=5f7a193256128, content=<a href='/topic/show?id=5cd95305803' target=_blank style='color:#2F92EE;'>#患者生存#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53058, encryptionId=5cd95305803, topicName=患者生存)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Sat Aug 26 19:37:00 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184911, encodeId=18b21849110d, content=禁烟是必要的!, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon Apr 03 17:13:13 CST 2017, time=2017-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184359, encodeId=521f18435922, content=烟厂, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/03/49a8b8e59b1110232178c436948997ae.jpg, createdBy=90151681386, createdName=哈夫, createdTime=Sat Apr 01 20:10:46 CST 2017, time=2017-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184041, encodeId=e5641840416a, content=很好的学习资料,谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161026/IMG58107C0F82E499574.jpg, createdBy=00e81970035, createdName=1e15b6fem30(暂无匿称), createdTime=Fri Mar 31 15:22:42 CST 2017, time=2017-03-31, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1864868, encodeId=8122186486895, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Aug 28 07:37:00 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1932561, encodeId=5f7a193256128, content=<a href='/topic/show?id=5cd95305803' target=_blank style='color:#2F92EE;'>#患者生存#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53058, encryptionId=5cd95305803, topicName=患者生存)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Sat Aug 26 19:37:00 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184911, encodeId=18b21849110d, content=禁烟是必要的!, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon Apr 03 17:13:13 CST 2017, time=2017-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184359, encodeId=521f18435922, content=烟厂, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/03/49a8b8e59b1110232178c436948997ae.jpg, createdBy=90151681386, createdName=哈夫, createdTime=Sat Apr 01 20:10:46 CST 2017, time=2017-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184041, encodeId=e5641840416a, content=很好的学习资料,谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161026/IMG58107C0F82E499574.jpg, createdBy=00e81970035, createdName=1e15b6fem30(暂无匿称), createdTime=Fri Mar 31 15:22:42 CST 2017, time=2017-03-31, status=1, ipAttribution=)]
    2017-04-03 大爰

    禁烟是必要的!

    0

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    2017-04-01 哈夫

    烟厂

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1864868, encodeId=8122186486895, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Aug 28 07:37:00 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1932561, encodeId=5f7a193256128, content=<a href='/topic/show?id=5cd95305803' target=_blank style='color:#2F92EE;'>#患者生存#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53058, encryptionId=5cd95305803, topicName=患者生存)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Sat Aug 26 19:37:00 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184911, encodeId=18b21849110d, content=禁烟是必要的!, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon Apr 03 17:13:13 CST 2017, time=2017-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184359, encodeId=521f18435922, content=烟厂, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/03/49a8b8e59b1110232178c436948997ae.jpg, createdBy=90151681386, createdName=哈夫, createdTime=Sat Apr 01 20:10:46 CST 2017, time=2017-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184041, encodeId=e5641840416a, content=很好的学习资料,谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161026/IMG58107C0F82E499574.jpg, createdBy=00e81970035, createdName=1e15b6fem30(暂无匿称), createdTime=Fri Mar 31 15:22:42 CST 2017, time=2017-03-31, status=1, ipAttribution=)]
    2017-03-31 1e15b6fem30(暂无匿称)

    很好的学习资料,谢谢了。

    0

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