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Ann Intern Med：大麻对成人慢性疼痛的疗效和危害分析！

2017-08-20 xing.T MedSci原创

大麻慢性疼痛效应危害
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由此可见，有限的证据表明大麻可以减轻某些病人的神经性疼痛，但对其他类型的慢性疼痛有效的证据不足。在一般人群中，有限的证据表明大麻与不良心理健康影响的风险增加有关。

大麻已越来越多地用于治疗慢性疼痛，但其疗效仍然不确定。近日，内科学权威杂志Annals of Internal Medicine上发表了一篇荟萃分析文章，研究人员旨在探讨以植物为基础的大麻制剂在治疗成人慢性疼痛的好处以及采用慢性疼痛和一般成人使用大麻的危害。

研究人员检索了MEDLINE、Cochrane系统评价数据库以及其他几个数据库，检索时间从数据库成立之时到2017年3月。研究人员选择研究的标准为：干预试验和观察性研究、以英语形式发表、参与者为使用植物性大麻制剂的成年人、参与者报告了疼痛、生活质量或不良反应的结局。两名研究者独立提取研究特征数据并评估研究质量，研究组使用严格的标准对证据的整体强度进行分级。

该荟萃分析从27个慢性疼痛试验得到强度较弱的证据表明，大麻可以减轻神经性疼痛，但对其他疼痛人群有效的证据不足。根据11项系统评价和32项原始研究，一般人群研究中的危害包括增加机动车事故风险、精神病症状和短期认知损害。虽然在年轻人群中没有观察到肺部不良反应，同样在重度或长期使用大麻的人或老年人中大多数其他长期身体损害的证据也明显不足。

由此可见，有限的证据表明大麻可以减轻某些病人的神经性疼痛，但对其他类型的慢性疼痛有效的证据不足。在一般人群中，有限的证据表明大麻与不良心理健康影响的风险增加有关。

原始出处：

Shannon M. Nugent,et al. The Effects of Cannabis Among Adults With Chronic Pain and an Overview of General Harms: A Systematic Review FREE. Ann Intern Med 2017. http://annals.org/aim/article/2648595/effects-cannabis-among-adults-chronic-pain-overview-general-harms-systematic

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    2017-09-14 sunfeifeiyang

    致幻剂

    0

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    2017-08-22 liubm555

    #慢性疼痛#

    0

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createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Aug 20 14:21:33 CST 2017, time=2017-08-20, status=1, ipAttribution=)]
    2017-08-22 kcb069

    #大麻#

    0

  4. 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03:17:00 CST 2017, time=2017-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272701, encodeId=6eef12e270150, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Tue Aug 22 03:17:00 CST 2017, time=2017-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607950, encodeId=9a7d160e950cc, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, 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createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Aug 20 16:36:33 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235424, encodeId=62bb23542498, content=学了。。。。。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Sun Aug 20 15:55:39 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235410, encodeId=b670235410b2, content=好文章，学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Aug 20 14:21:33 CST 2017, time=2017-08-20, status=1, ipAttribution=)]
    2017-08-22 ms3994565386320060

    #Med#

    0

  5. 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03:17:00 CST 2017, time=2017-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272701, encodeId=6eef12e270150, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Tue Aug 22 03:17:00 CST 2017, time=2017-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607950, encodeId=9a7d160e950cc, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, 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createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Aug 20 16:36:33 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235424, encodeId=62bb23542498, content=学了。。。。。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Sun Aug 20 15:55:39 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235410, encodeId=b670235410b2, content=好文章，学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Aug 20 14:21:33 CST 2017, time=2017-08-20, status=1, ipAttribution=)]
    2017-08-21 戒馋，懒，贪

    谢谢分享，学习了

    0

  6. 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createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Aug 20 16:36:33 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235424, encodeId=62bb23542498, content=学了。。。。。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Sun Aug 20 15:55:39 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235410, encodeId=b670235410b2, content=好文章，学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Aug 20 14:21:33 CST 2017, time=2017-08-20, status=1, ipAttribution=)]
    2017-08-20 有备才能无患

    在一般人群中，有限的证据表明大麻与不良心理健康影响的风险增加有关。

    0

  7. 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createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Aug 20 14:21:33 CST 2017, time=2017-08-20, status=1, ipAttribution=)]
    2017-08-20 thlabcde

    好东西学习了！

    0

  8. 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createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Aug 20 16:36:33 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235424, encodeId=62bb23542498, content=学了。。。。。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Sun Aug 20 15:55:39 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235410, encodeId=b670235410b2, content=好文章，学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Aug 20 14:21:33 CST 2017, time=2017-08-20, status=1, ipAttribution=)]
    2017-08-20 忠诚向上

    好好学习，会有收获

    0

  9. 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createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Aug 20 16:36:33 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235424, encodeId=62bb23542498, content=学了。。。。。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Sun Aug 20 15:55:39 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235410, encodeId=b670235410b2, content=好文章，学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Aug 20 14:21:33 CST 2017, time=2017-08-20, status=1, ipAttribution=)]
    2017-08-20 135****7952平儿

    学了。。。。。。。。。。

    0

  10. 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createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Aug 20 14:21:33 CST 2017, time=2017-08-20, status=1, ipAttribution=)]
    2017-08-20 1e0f8808m18(暂无匿称)

    好文章，学习了。

    0

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