ESC 2014:侧支循环对于因颅内动脉闭塞所致急性缺血性卒中患者行神经切除术的预后价值

2014-07-02 国际循环 国际循环

2014年欧洲卒中大会(ESC)上,意大利Tor Vergata大学F. Sallustio等报告了一项研究。已知颅内侧支循环(ICF)与急性缺血性卒中(AIS)患者功能预后有关。该研究旨在评估ICF对颅内前循环动脉闭塞患者的预后价值。研究回顾性分析患者神经血栓切除术(NT)治疗前非造影CT(NCT)、CT血管造影(CTA)、数字减影血管造影(DSA)和治疗后MRI。根据CTA与DSA结果对ICF

2014年欧洲卒中大会(ESC)上,意大利Tor Vergata大学F. Sallustio等报告了一项研究。已知颅内侧支循环(ICF)与急性缺血性卒中(AIS)患者功能预后有关。该研究旨在评估ICF对颅内前循环动脉闭塞患者的预后价值。研究回顾性分析患者神经血栓切除术(NT)治疗前非造影CT(NCT)、CT血管造影(CTA)、数字减影血管造影(DSA)和治疗后MRI。根据CTA与DSA结果对ICF有效性进行评分。根据NCT、CTA和MR-DWI计算ASPECTS评分。并评估3个月的mRS评分。

接受NT治疗的113例患者中,95/113(84%)有前循环卒中。74/95(78%)有侧支数据。基于DSA检查,患者被分为ICF好(1~2;n=45)或差(3~5;n=29)组。CTA评分系统的敏感度和特异性优于DSA(分别为87%和77%)。与ICF差组相比,ICF好组患者CTA(6.1±1.77 vs. 3.2±2.48,P<0.0001)、NCT(7.53±1.19 vs. 6.3±1.97,P=0.0001)和MR-DWI(4.62±2.32 vs. 1.5±1.29,P=0.007)的ASPECTS评分较高,且MR-DWI中病变体积显著较小。另外,出院时ICF好组患者预后良好(如mRS评分<2)比例更高(13/45 vs. 1/29,P=0.006),死亡率更低(2/45 vs. 8/29,P=0.004)。3个月预后良好的独立预测因子是CTA ASPECTS评分(6.1 vs. 3.2,P=0.01)及发病和出院前NIHSS改善(-11.4 vs. 5.8,P=0.008)。

结论认为,侧支循环好的AIS患者出院时预后良好且死亡率较低。出院时NIHSS显著改善和好的CTA ASPECTS评分是3个月预后良好的独立预测因子。

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