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Clinica Chimica Acta：血清抗磷脂酶A2受体抗体对糖尿病肾病患者特发性膜性肾病的诊断价值

2020-04-12 MedSci原创 MedSci原创

肾病；诊断价值
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在肾病人群特发性膜性肾病(IMN)诊断中，血清抗磷脂酶A2受体(抗pla2r)抗体具有较高的准确性。然而，抗pla2r抗体对糖尿病肾病(DKD) IMN的诊断价值尚不明确。

在肾病人群特发性膜性肾病(IMN)诊断中，血清抗磷脂酶A2受体(抗pla2r)抗体具有较高的准确性。然而，抗pla2r抗体对糖尿病肾病(DKD) IMN的诊断价值尚不明确。本研究的目的是确定该标志物在DKD人群中的诊断效能和最佳截断值。

本研究纳入2016年5月至2018年1月中国人民解放军总医院肾病科227例2型糖尿病患者，经肾活检病理诊断。通过酶联免疫吸附法检测该人群的pla2r抗体。根据病理结果分为IMN组和非膜性肾病(non- ous nephropathy, non-MN)组。分析临床特征，评估抗pla2r抗体的诊断能力，构建受试者工作特征(ROC)曲线，获得最佳截断值。

IMN组中有45名患者，占研究样本的19.8％。 该组患者在进行肾脏活检时比非MN组年龄更大，糖尿病病程更短，血糖控制更好，血压和尿酸更低，肾功能更好。 另外，他们的临床症状表明肾病综合症。 诊断DKD中IMN的抗PLA2R抗体的最佳临界值为2.71 Ru / ml，灵敏度为0.800，特异性为0.951，阳性预测值为0.800，阴性预测值为0.951，准确性为0.921， Yoden指数为0.750。 ROC曲线下的面积为0.87（95％CI，0.788–0.952）（p <0.001）。

研究结果表明，IMN组患者年龄较大，肾功能较好，病情一般，临床症状提示肾病综合征。在DKD人群中，Anti-PLA2R抗体对IMN有较好的诊断效果，最佳截断值为2.71。

原始出处：

Qian Wang，Zhe-yi Dong，Diagnostic efficacy of serum anti-phospholipase A2 receptor antibodies for idiopathic membranous nephropathy in patients with diabetic kidney disease

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    2020-10-10 windight

    #CTA#

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    2020-06-18 gostraight

    #肾病患者#

    0

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    2020-04-16 日月

    #特发性膜性肾病#

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    2020-08-28 xinxin088

    #特发性#

    0

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    2020-06-28 medscijoin

    #诊断价值#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1849900, encodeId=ef7b184990043, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sat Oct 10 15:42:57 CST 2020, time=2020-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025882, encodeId=8ba32025882f4, content=<a href='/topic/show?id=a91d82583bf' target=_blank style='color:#2F92EE;'>#肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82583, encryptionId=a91d82583bf, topicName=肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Thu Jun 18 10:42:57 CST 2020, time=2020-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027223, encodeId=981f202e22323, content=<a href='/topic/show?id=802a6e9016d' target=_blank style='color:#2F92EE;'>#特发性膜性肾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67901, encryptionId=802a6e9016d, topicName=特发性膜性肾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4a4d285, createdName=日月, createdTime=Thu Apr 16 15:42:57 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1894767, encodeId=42d71894e6775, content=<a href='/topic/show?id=e45b6e859f3' target=_blank style='color:#2F92EE;'>#特发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67859, encryptionId=e45b6e859f3, topicName=特发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Fri Aug 28 12:42:57 CST 2020, time=2020-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1721686, encodeId=aea41e2168613, content=<a href='/topic/show?id=39d6915e9bf' target=_blank style='color:#2F92EE;'>#诊断价值#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91579, encryptionId=39d6915e9bf, topicName=诊断价值)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7c7d33065043, createdName=medscijoin, createdTime=Sun Jun 28 16:42:57 CST 2020, time=2020-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043068, encodeId=dc461043068b5, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Apr 13 00:42:57 CST 2020, time=2020-04-13, status=1, ipAttribution=)]
    2020-04-13 misszhang

    谢谢MedSci提供最新的资讯

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