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Neurology：女性β2-微球蛋白水平与缺血性卒中风险相关

2017-05-11 xing.T MedSci原创

β2-微球蛋白女性卒中
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由此可见，高浓度的B2M与女性缺血性中风的风险增加相关。

近日，神经病学领域权威取杂志Neurology上发表了一篇研究文章，研究人员旨在确定升高的β2-微球蛋白（B2M）水平是否与女性缺血性脑卒中事件的发生风险增加相关。

研究人员对护士健康研究中的妇女进行了巢式病例对照研究，她们在1989到1990年期间提供了血液样本，并且之前没有发生脑卒中和癌症。研究人员测定了473例经病历证实的缺血性卒中病例及473例对照者的B2M水平，这些对照者以1:1的比例病例在年龄、种族、采血日期、绝经状态、绝经后激素的使用和吸烟状况进行匹配。研究人员应用调整了传统卒中危险因素的多元条件Logistic回归分析了B2M水平与缺血性脑卒中之间的关系。

研究人员发现病例B2M水平的中位数都较高（1.86mg/L）相比于对照者（1.80mg/L，P=0.009，Wilcoxon秩和检验）。与B2M水平在最低四分位数的妇女相比，那些在最高四分位数的女性多变量调整后的缺血性中风的风险增加（比值比[OR]为1.56，95%可信区间[CI]为1.02-2.39）。当局限于那些没有慢性肾脏疾病证据的参与者（估计肾小球滤过率≥60ml•min-1•1.73m-2）结果是类似的（OR为1.49，95%CI为1.08-2.06）。在探索性分析中，B2M水平和血栓性卒中之间的关系类似于整体缺血性卒中的结果，但在栓塞性卒中风险中没有观察到关联。

由此可见，高浓度的B2M与女性缺血性中风的风险增加相关。

原始出处：

Pamela M. Rist,et al. Prospective association between β2-microglobulin levels and ischemic stroke risk among women. Neurology. 2017. http://dx.doi.org/10.1212/WNL.0000000000004006

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    2017-08-09 xzw113

    #球蛋白#

    0

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    2018-02-27 12498da4m32(暂无昵称)

    #缺血性卒#

    0

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    2017-06-29 海棠胜雪

    学习了

    0

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    2017-10-23 guihongzh

    #缺血性#

    0

  5. 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    2017-07-21 zywlvao

    #β2-微球蛋白#

    0

  6. 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createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Fri May 12 12:51:20 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196970, encodeId=6dbd1969e077, content=为什么只做与女性缺血性卒中的相关性哩，与男性的，总体人群的呢？, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1KhsAicmWjyJ4riaHCUWKCO5xRX3Py4CRHVRBKgz0TINsjQO4A5AqMcBOreWQQ6wvLOOsPKbKeEKW/0, createdBy=4acb1986920, createdName=syajq, createdTime=Fri May 12 08:26:42 CST 2017, time=2017-05-12, status=1, ipAttribution=)]
    2017-09-16 yinhl1978

    #Neurol#

    0

  7. 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encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Mon Oct 23 10:25:00 CST 2017, time=2017-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2077311, encodeId=f49f20e7311cb, content=<a href='/topic/show?id=09ac1921127' target=_blank style='color:#2F92EE;'>#β2-微球蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19211, encryptionId=09ac1921127, topicName=β2-微球蛋白)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKeia4TJeMGvEH3wKKIBNjuHuIic1HDNOB10j4tCd3nbylxkxm6HSMfEaKkSu6OZOak4uZv7UVicsWEg/132, createdBy=bc9a2500116, createdName=zywlvao, createdTime=Fri Jul 21 04:25:00 CST 2017, time=2017-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999934, encodeId=0a681999934b4, 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createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Fri May 12 12:51:20 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196970, encodeId=6dbd1969e077, content=为什么只做与女性缺血性卒中的相关性哩，与男性的，总体人群的呢？, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1KhsAicmWjyJ4riaHCUWKCO5xRX3Py4CRHVRBKgz0TINsjQO4A5AqMcBOreWQQ6wvLOOsPKbKeEKW/0, createdBy=4acb1986920, createdName=syajq, createdTime=Fri May 12 08:26:42 CST 2017, time=2017-05-12, status=1, ipAttribution=)]
    2017-05-13 1e1b8c04m38(暂无匿称)

    学习

    0

  8. 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createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Fri May 12 12:51:20 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196970, encodeId=6dbd1969e077, content=为什么只做与女性缺血性卒中的相关性哩，与男性的，总体人群的呢？, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1KhsAicmWjyJ4riaHCUWKCO5xRX3Py4CRHVRBKgz0TINsjQO4A5AqMcBOreWQQ6wvLOOsPKbKeEKW/0, createdBy=4acb1986920, createdName=syajq, createdTime=Fri May 12 08:26:42 CST 2017, time=2017-05-12, status=1, ipAttribution=)]
    2017-05-12 仁心济世

    #卒中风险#

    0

  9. 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createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Fri May 12 12:51:20 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196970, encodeId=6dbd1969e077, content=为什么只做与女性缺血性卒中的相关性哩，与男性的，总体人群的呢？, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1KhsAicmWjyJ4riaHCUWKCO5xRX3Py4CRHVRBKgz0TINsjQO4A5AqMcBOreWQQ6wvLOOsPKbKeEKW/0, createdBy=4acb1986920, createdName=syajq, createdTime=Fri May 12 08:26:42 CST 2017, time=2017-05-12, status=1, ipAttribution=)]
    2017-05-12 绛珠草小姐

    学习了，谢谢

    0

  10. 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    2017-05-12 syajq

    为什么只做与女性缺血性卒中的相关性哩，与男性的，总体人群的呢？

    0

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